Pesticide Concentrations in Matrices Collected in the Perinatal Period in a Population of Pregnant Women and Newborns in New Jersey,USA |
| |
Authors: | Xiaoyong Yan Susan Lashley John C Smulian Cande V Ananth Dana B Barr Thomas A Ledoux |
| |
Institution: | 1. Joint Graduate Program in Toxicology, Rutgers, the State University of New Jersey/UMDNJ , Piscataway, NJ, USA;2. Department of Obstetrics, Gynecology, and Reproductive Sciences , University of Virginia , Charlottesville, VA, USA;3. Department of Obstetrics and Gynecology , Lehigh Valley Hospital , Allentown, PA, USA;4. Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences , UMDNJ-Robert Wood Johnson Medical School , New Brunswick, NJ, USA;5. Division of Laboratory Sciences , National Center for Environmental Health, Centers for Disease Control and Prevention , Atlanta, GA, USA;6. Risk Assessment &7. Toxicology Section, Division of Science, Research &8. Technology, New Jersey Department of Environmental Protection , Trenton, NJ, USA |
| |
Abstract: | Gestational exposure to pesticides may adversely affect fetal development and birth outcomes. However, data on fetal exposure and associated health effects in newborns remain sparse. We measured a variety of pesticides and metabolites in maternal urine, maternal serum, cord serum, amniotic fluid, and meconium samples collected at the time of cesarean delivery from 150 women in central New Jersey, USA. Women who used pesticides at home had higher concentrations of pesticides or metabolites in cord serum e.g., dacthal (p = .007), diethyltoluamide (p = .043), and phthalimide (p = .030)] than those who did not use pesticides, suggesting that residential use of pesticides may contribute to overall exposure as assessed by biomonitoring. Except for orthophenylphenol, the concentrations of most pesticides in biological matrices of this study population were either comparable to or lower than the levels reported in previous studies and in the U.S. general population. The daily exposure estimates of two representative organophosphorus insecticides (chlorpyrifos and diazinon) were lower than most regulatory protection limits (USEPA oral benchmark dose10/100, USEPA reference oral dose, or ATSDR minimal risk levels); however, they were near or at the USEPA's population-adjusted doses for children and women. No abnormal birth outcomes or other clinical endpoints were noted in those newborns who had higher concentrations of orthophenylphenol during the perinatal period. |
| |
Keywords: | pesticides urine blood amniotic fluid exposure assessment pregnant women children |
|
|