氨茶碱及高压氧治疗老年呼吸衰竭疗效及对患者肺功能影响

摘要 目的：探讨氨茶碱及高压氧治疗老年呼吸衰竭疗效及对患者肺功能影响。方法：采取回顾性研究法，选择2016年8月到2021年5月在本院诊治的老年呼吸衰竭患者84例作为研究对象，以随机1:1数字表法方式把患者平均分为对照组和联合组各42例。两组都给予无创机械通气治疗，对照组给予雾化吸入氨茶碱治疗，联合组在对照组治疗的基础上给予高压氧治疗，两组都治疗观察14 d。结果：两组治疗后的动脉血氧分压（PaO₂）值显著升高，动脉二氧化碳分压（PaCO₂）值显著降低，对比存在明显差异，治疗后联合组的PaCO₂、PaO₂值与对照组对比存在明显差异（P<0.05）。治疗后，联合组总有效率为97.6 %，高于对照组83.3 %（P<0.05）。治疗后，联合组与对照组的一秒用力呼气容积（FEV₁）/用力肺活量（FVC）值都明显高于治疗前，联合组明显高于对照组（P<0.05）。治疗后联合组与对照组的血清白细胞介素（IL）-6、IL-10水平都呈现明显下降趋势，且联合组明显低于对照组（P<0.05）。结论：氨茶碱联合高压氧治疗老年呼吸衰竭能抑制IL-6、IL-10的表达，改善机体的血气状况与肺功能，提高总体治疗效果，减少并发症的发生，值得在临床上推广使用。

Efficacy of Aminophylline and Hyperbaric Oxygen in the Treatment of Senile Respiratory Failure and Their Effects on Pulmonary Function

ABSTRACT Objective: To investigate the efficacy of aminophylline and hyperbaric oxygen in the treatment of elderly patients with respiratory failure and their effects on pulmonary function. Methods: Used a retrospective study method, from August 2016 to May 2021, 84 caes of elderly patients with respiratory failure who were diagnosed and treated in our hospital were selected as the research objects, and the patients were equally divided into the control group and the combination group by random 1:1 digital table method. Both groups were treated with non-invasive mechanical ventilation, the control group were treated with nebulized aminophylline, and the combination group were treated with hyperbaric oxygen on the basis of the treatment of the control group. Both groups were treated for 14 days. Results: After treatment, the PaO₂ values of the two groups were significantly increased, and the PaCO₂ values were decreased, and there were difference compared between the two groups(P<0.05). The total effective rates after treatment in the combination group were 97.6 %, which were significantly higher than 83.3 % in the control group (P<0.05). After treatment, the FEV₁/FVC values of the combination group and the control group were significantly higher than those before treatment(P<0.05), and the combination group were higher than that before treatment, and were higher than the control group(P<0.05). After treatment, the serum interleukin(IL)-6 and IL-10 levels in the combination group and the control group were showed significant downward trend, and the combination group were lower than the control group(P<0.05). Conclusion: Aminophylline combined with hyperbaric oxygen in the treatment of elderly respiratory failure can inhibit the expression of IL-6 and IL-10, improve the body''s blood gas status and lung function, improve the overall treatment effect, and reduce the incidence of complications, which is worthy of clinical promotion.