血清胃蛋白酶原Ⅰ/Ⅱ、铁蛋白及肿瘤坏死因子-alpha对胃癌的诊断价值

目的：探讨血清胃蛋白酶原Ⅰ/Ⅱ(PGⅠ/Ⅱ)、铁蛋白、肿瘤坏死因子-alpha联合检查诊断胃癌的临床意义。方法：选择2013 年5 月至2014 年10 月收治的胃病住院患者及健康体检者，根据胃镜及病理组织学结果，将其分良性胃病组、胃癌组以及健康组，比 较三组血清胃蛋白酶原Ⅰ/Ⅱ、铁蛋白及肿瘤坏死因子-alpha水平，分析血清胃蛋白酶原Ⅰ/Ⅱ(PGⅠ/Ⅱ)、铁蛋白、肿瘤坏死因子-alpha单 独和联合诊断胃癌的敏感性、特异性和准确性。结果：与健康组比较，良性胃病组以及胃癌组的血清PGⅠ/Ⅱ水平较低(P＜0.05)， 与良性胃病组比较，胃癌组血清PGⅠ/Ⅱ水平较低(P＜0.05)；与健康组比较，良性胃病组以及胃癌组的血清铁蛋白以及TNF-alpha水 平较高(P＜0.05)，与良性胃病组比较，胃癌组血清铁蛋白以及TNF-alpha水平较高(P＜0.05)。PGⅠ/Ⅱ、铁蛋白以及TNF-alpha联合检测 诊断胃癌的敏感度以及准确度分别为88.4％以及83.1％，高于单一检测。结论：血清PGⅠ/Ⅱ、血清铁蛋白、肿瘤坏死因子-alpha联合 检测诊断胃癌的效能优于单一检测。

Analysis of the Clinical Value of Combined Examination of Serum Pepsinogen, Ferritin, Tumor Necrosis Factor -alpha in the Diagnosis of Gastric Cancer

Objective:To analyze the levels of serumPG I/II, ferritin and tumor necrosis factor-alpha(TNF-alpha) in the diagnosis of gastric cancer.Methods:Gastric disease patients hospitalized in our hospital fromMay 2013 to Oct 2014 and healthy persons were selected divided into stomach group, gastric cancer group and the control group according to the endoscopy and histopathology results. The serum pepsinogen I/II, ferritin and TNF-alpha levels were compared between different groups. The sensitivity, specificity and accuracy of serum pepsinogen I/II, ferritin and TNF-alpha in the diagnosis of gastric cancer were analyzed.Results:Compared with the control group, the serum pepsinogen I/II levels of benign stomach group and gastric cancer group were lower (P<0.05), compared with the benign stomach group, the serum pepsinogen I/II levels of gastric cancer group was lower (P<0.05). Compared with the control group, the serum ferritin and TNF-alpha levels of benign stomach group and gastric cancer group were higher (P<0.05), compared with the benign stomach group, the serum ferritin and TNF-alpha levels of gastric cancer group was higher (P<0.05). The sensitivity and accuracy of serum PG I/II, ferritin and TNF-alpha combined detection of gastric cancer were 83.1%and 88.4%respectively, and they were higher than the single detection.Conclusion:The efficiency of combined detection with serumpepsinogen I/II, ferritin, TNF-alpha was superior to single detection in the diagnosis of gastric cancer.