SUMF2对炎症的影响

炎症是机体的一种适应性反应,失调时将会对自身机体造成损伤。研究表明许多疾病的发生发展均与炎症的失调有关。硫酸酯酶作为人体不可或缺的蛋白质家族与炎症之间有着密切关联。发热是炎症最主要的表现形式,硫酸酯酶修饰因子2(sulfatase-modifying factor 2,SUMF2)参与硫酸酯酶的激活且与发热密切相关。脂多糖刺激人体后,SUMF2的表达明显降低。SUMF2已被证实与白细胞介素-13(Interleukin-13,IL-13)之间存在相互作用,且能在体外水平抑制IL-13的分泌,IL-13可以通过抑制炎性因子的产生发挥抗炎作用。本文将就硫酸酯酶、SUMF2及其对炎症之间的影响进行综述。

The Effect of SUMF2 on Inflammation

ABSTRACT: Inflammation is an adaptive response to the body, which will cause damage to the body. Research shows that the de- velopment of many diseases is related to the disorder of inflammation. As an indispensable protein family of the human body, the sulfated enzyme has a close association with inflammation. Sulfatase esterase Modifier 2 (SUMF2) is involved in the activation of sulfate esterase and is closely related to fever. Fever is the most important manifestation of inflammation. After the lipopolysaccharide stimulated the hu- man body, the expression of the SUMF2 was significantly reduced. SUMF2 has been confirmed to interact with interleukin -13 (IL-13) and can inhibit IL-13 secretion in vitro. IL-13 can play an anti-inflammatory role by inhibiting the production of inflammatory factors. This article will review the effect of sulfated esterase, SUMF2 and their effect on inflammation.