17号染色体不同倍体与乳腺癌临床病理特征的相关性

摘要 目的：探讨17号染色体不同倍体与乳腺癌临床病理特征的相关性。方法：选取2018年1月至2019年12月确诊为乳腺癌的患者78例(乳腺癌组)与乳腺良性肿瘤患者78例(良性组)，采用原位荧光杂交检测所有患者的病灶组织染色体不同倍体情况，分析患者的临床病理特征并进行相关性分析。结果：乳腺癌组17号染色体的多倍体率为85.9 %，显著高于良性组(3.8 %，P<0.05)。不同年龄、性别、发病位置、病理类型乳腺癌患者的17号染色体多倍体率对比差异无统计学意义(P>0.05)，不同淋巴结转移、组织学分化、临床分期、ER阳性、PR阳性患者的17号染色体多倍体率对比差异具有统计学意义(P<0.05)。Pearson分析显示17号染色体多倍体率与乳腺癌患者的淋巴结转移、组织学分化、临床分期、ER阳性、PR阳性存在显著相关性(P<0.05)；多因素Logistic回归分析显示淋巴结转移、组织学分化、临床分期、ER阳性、PR阳性都为17号染色体多倍体的主要危险影响因素(P<0.05)。结论：乳腺癌患者多伴随有17号染色体多倍体，与其患者的淋巴结转移、组织学分化、临床分期、ER阳性、PR阳性等临床病理特征显著相关。

Correlation between Different Ploidy of Chromosome 17 and Clinicopathological Features of Breast Cancer

ABSTRACT Objective: To explore the correlation between different ploidy of chromosome 17 and clinicopathological features of breast cancer. Methods: 78 patients with breast cancer (breast cancer group) and 78 patients with benign breast tumors (benign group) were selected from January 2018 to December 2019. All patients'' tissue samples were collected and in situ fluorescence hybridization was used for detection of different ploidy of chromosomes, and were given investigation of clinicopathological characteristics of patients and correlation analysis. Results: The polyploid rate of chromosome 17 in breast cancer group was 85.9 %, which was significantly higher than that in benign group (3.8 %, P<0.05). There were no significant difference in the polyploid rate of chromosome 17 in patients of different ages, genders, locations of pathology, and pathological types (P>0.05). The difference in polyploid rates of chromosome 17 were statistically significant in lymph node metastasis, histological differentiation, clinical staging, ER positive, PR positive(P<0.05). Pearson analysis showed that there were correlation between lymph node metastasis, histological differentiation, clinical staging, ER positive, PR positive, and polyploidy rate of chromosome 17 in patients with breast cancer (P<0.05). Multivariate Logistic regression analysis showed that histological differentiation, clinical staging, ER-positive, and PR-positive were the main risk factors for the polyploidy rate of chromosome 17(P<0.05). Conclusion: Breast cancer patients was often accompanied by polyploids of chromosome 17, which were significantly related to clinical and pathological features such as lymph node metastasis, histological differentiation, clinical staging, ER positive, and PR positive.