热声成像技术及其在生物医学中的研究进展

摘要：成像技术在疾病的诊断、治疗和监测中起着重要的作用。热声成像作为一种非电离和非侵入性的新型生物医学成像技术，结合了微波成像高对比度和超声成像高分辨率的优点。因其具有利用内源性对比剂（如水和离子）或多种外源性对比剂（或两者兼有）提供结构、功能、和分子信息的能力，在预临床和临床应用中显示出了巨大的潜力。近几十年来，由于微波辐射源和超声硬件的不断发展，热声成像技术已被广泛用于生物医学成像领域。本文阐述了热声成像的基本原理及成像特点，介绍了近年来热声成像技术在生物医学上的应用、当前在解决相应临床问题应用中的优势及研究现状，最后针对热声成像技术在现有生物医学中面临的挑战对该技术进行了展望。

Thermoacoustic Imaging Technology and Its Research Progress in Biomedicine

ABSTRACT: Imaging modalities play an important role in disease diagnosis, treatment and therapy monitoring. Thermoacoustic imaging (TAI) is a novel non-invasive and non-ionizing biomedical imaging technology availing the benefits of high contrast (microwave imaging) and high resolution (ultrasound imaging). With its capacity to offer structural, functional and molecular information making use of either endogenous contrast agents like water and ion or a variety of exogenous contrast agents or both, TAI has demonstrated promising potential in a wide range of preclinical and clinical applications. In recent decades, as a result of the continuous development of microwave radiation sources and ultrasound hardware, the TAI technology has been extensively utilized to achieve biomedical imaging. This article describes the basic principles and imaging characteristics of TAI, introduces the application of TAI in biomedicine and the advantages and current research status of TAI in solving corresponding clinical problems in recent years. Finally, The future development of TAI in the challenges of current biomedicine has also prospected.