冠心病患者CTA影像学特征与血浆前蛋白转化酶枯草杆菌蛋白酶9及血清可溶性ST2的相关性分析

摘要 目的：探究冠心病患者螺旋CT冠状动脉血管造影（CTA）影像学特征与血浆前蛋白转化酶枯草杆菌蛋白酶9（proprotein convrtase subtilisin/kexin 9，PCSK-9）以及血清可溶性ST2的相关性。方法：选择2015年8月到2020年8月我院接受治疗的90例冠心病患者为实验组，另选取同期于我院接受治疗的50例非冠心病患者为对照组，首先对比两组患者PCSK-9以及可溶性ST2水平，而后将实验组患者按照CTA检测结果区分为无冠脉狭窄组（13例）、轻度冠脉狭窄组（31例）、中度冠脉狭窄组（29例）以及重度冠脉狭窄组（17例），对比四组冠心病患者PCSK-9以及可溶性ST2水平，探究冠心病患者不同冠脉狭窄程度相关因素。结果：（1）实验组患者PCSK-9以及可溶性ST2水平均明显高于对照组患者，组间差异明显（P<0.05）；（2）随着冠脉狭窄程度的升高，冠心病患者的PCSK-9以及可溶性ST2水平也呈现明显升高趋势，4组间比较差异具有统计学意义（P<0.05）；（3）单因素分析显示高血压、糖尿病、吸烟、PCSK-9>335 ng/mL、可溶性ST2>35 ng/mL是冠状动脉狭窄的危险因素；（4）多因素Logistic分析显示PCSK-9、可溶性ST2水平均与冠状动脉狭窄相关（P<0.05）。结论：PCSK-9以及可溶性ST2水平与冠心病患者CTA影响学特征具有一定的相关性，上述因子水平越高，冠心病患者冠脉狭窄程度越严重。

The Correlation Analysis of CTA Imaging Features with Plasma Pro protein Invertase Subtilisin 9 and Serum Soluble ST2 in Patients with Coronary Heart Disease

ABSTRACT Objective: To investigate the correlation between spiral CT coronary angiography (CTA) imaging features and proprotein convrtase subtilisin/kexin 9 (PCSK-9) and serum soluble ST2 in patients with coronary heart disease. Methods: 90 patients with coronary heart disease who were treated in our hospital from August 2015 to August 2020 were selected as the experimental group, and 50 patients without coronary heart disease who were treated in our hospital during the same period were selected as the control group. The pcsk-9 and soluble ST2 levels of the two groups were compared, and then the patients in the experimental group were divided into no coronary stenosis group (13 cases), mild coronary stenosis group (31 cases) and moderate coronary artery stenosis group (middle group) according to the CTA test results The levels of pcsk-9 and soluble ST2 were compared among the four groups, and the related factors of different degree of coronary artery stenosis were explored. Results: (1) The levels of PCSK-9 and soluble ST2 in the experimental group were significantly higher than those in the control group, and the difference between the groups was significant(P<0.05). (2) As the degree of coronary stenosis increased, the PCSK-9 and soluble ST2 levels also showed a significant increase trend, the difference between the four groups was statistically significant (P<0.05). (3) Univariate analysis showed that hypertension, diabetes, smoking, PCSK-9>335 ng/mL. Soluble ST2>35 ng/mL is a risk factor for coronary artery stenosis. (4) Multivariate logistic analysis shows that PCSK-9 and soluble ST2 levels are related to coronary artery stenosis (P<0.05). Conclusion: The levels of PCSK-9 and soluble ST2 have a certain correlation with the CTA impact characteristics of patients with coronary heart disease. The higher the above factors, the more severe the coronary stenosis in patients with coronary heart disease.