超声造影定量与动态增强MRI定量在宫颈癌诊断中的应用价值

摘要 目的：探究超声造影定量与动态增强MRI定量在宫颈癌诊断中的应用价值。方法：选择2016年1月至2019年1月于我院接受治疗的86例疑似宫颈癌患者为实验组，另选取同期于我院接受治疗的50例宫颈良性病变患者为对照组，分别对两组患者实施超声造影定量检测及动态增强MRI检查，对比两组患者各参数组间差异性，同时以病理学检测结果为金标准，分析两种检查手段对宫颈癌的筛查效果并实施组间比较。结果：（1）比较显示实验组患者的峰值强度（peak intensity，PI）及时间-曲线下面积（area under curve，AUC）均高于对照组，达峰时间（time to peak，TTP）及平均渡越时间（mean transit time，MTT）均低于对照组（P<0.05）；（2）比较显示实验组患者的容积转移常数（volume transfer constant，K ^trans ）、速率常数（rate constant，k _ep ）以及血管外细胞外容积分数（extravascular extracellular volume fraction，V _e ）均高于对照组，表观扩散系数（apparent diffusion coefficient，ADC）低于对照组（P<0.05）；（3）以病理学检测结果为金标准，超声造影定量检测对宫颈癌检测一致性为93.02 %，灵敏度为94.44 %，特异度为85.71 %，增强MRI对宫颈癌检测一致性为96.51%，灵敏度为98.61%，特异度为85.71%。结论：宫颈癌患者实施超声造影定量与增强MRI检测时检测参数与正常宫颈组织相比会出现明显的差异性，可将上述两种检测方式用于宫颈癌患者的筛查诊断中。

Contrast-enhanced Ultrasound Quantification and Dynamic Enhanced MRI Quantification in the Diagnosis of Cervical Cancer

ABSTRACT Objective: To explore the value of contrast-enhanced ultrasound quantification and dynamic contrast-enhanced MRI quantification in the diagnosis of cervical cancer; Methods: 86 patients with suspected cervical cancer who were treated in our hospital from January 2016 to January 2019 were selected as the experimental group. Fifty patients with benign cervical lesions treated in our hospital during the same period were selected as the control group. Quantitative contrast-enhanced ultrasound and dynamic enhanced MRI were performed on the two groups of patients, and the differences between the two groups of parameters were compared. The result is the gold standard. The screening effect of the two screening methods on cervical cancer is analyzed and the comparison between groups is performed. Results: The comparison shows that the peak intensity (PI) and time-curve area (AUC) of the experimental group are high. In the control group, the peak time (TTP) and mean transit time (MTT) were lower than the control group (P<0.05). The comparison showed that the volume transfer constant (K ^trans ) and rate constant (k _ep ) of the experimental group of patients The extravascular extracellular volume fraction (V _e ) was higher than that of the control group, and the apparent diffusion coefficient (ADC) was lower than that of the control group (P<0.05). Based on the pathological test results, the gold standard, Quantitative sonography for cervical cancer has a consistency of 93.02 %, sensitivity of 94.44 %, and specificity of 85.71 %. Enhanced MRI has a consistency of 96.51 %, sensitivity of 98.61 %, and specificity of 85.71 % for cervical cancer. Conclusion: The detection parameters of cervical cancer patients undergoing quantitative ultrasound contrast and enhanced MRI detection will show significant differences compared with normal cervical tissues. The above two detection methods can be compared. Used in the screening diagnosis of cervical cancer patients.