上皮性卵巢癌患者组织P53、Ki67表达及其临床意义

摘要 目的：探讨上皮性卵巢癌患者组织P53、Ki67表达及其临床意义。方法：选择卵巢肿瘤102例，其中病理诊断为良性卵巢肿瘤40例(良性组)和上皮性卵巢癌62例(恶性组)，采用免疫组化法检测组织P53、Ki67表达水平，调查患者的临床病理特征并进行相关性分析。结果：恶性组的P53、Ki67表达阳性率为80.6 %和72.6 %，显著高于良性组的10.0 %和12.5 %(P<0.05)。在恶性组中，不同浸润转移、分化程度、病理分期患者的P53、Ki67表达阳性率对比差异有统计学意义(P<0.05)。直线相关分析显示上皮性卵巢癌患者P53表达阳性率与Ki67表达阳性率呈现显著正相关性(r=0.872，P=0.000)。多因素logistic回归分析显示浸润转移、分化程度、病理分期都为影响P53、Ki67表达阳性率的主要因素(P<0.05)。结论：上皮性卵巢癌患者组织P53、Ki67都呈现高表达状况，与患者的临床病理特征显著相关，两者也可互相影响，共同参与上皮性卵巢癌的发生与发展。

Expression of P53 and Ki67 in Patients with Epithelial Ovarian Cancer and Its Clinical Significance

ABSTRACT Objective: To investigate the expression of P53 and Ki67 in patients with epithelial ovarian cancer and its clinical significance. Methods: 102 patients with ovarian tumors were selected and treated, including 40 cases of benign ovarian tumors (benign group) and 62 cases of epithelial ovarian cancer (malignant group). The expression levels of P53 and Ki67 were detected by chemical method, and the clinicopathological features of the patients were investigated and correlation analysis were performed. Results: The positive rates of P53 and Ki67 expression in the malignant group were 80.6 % and 72.6 %, which were significantly higher than those in the benign group (10.0 % and 12.5 %)(P<0.05). In the malignant group, the positive rates of P53 and Ki67 expression in patients with different invasive metastasis, differentiation and pathological stage were statistically significant (P<0.05). Linear correlation analysis showed that the positive rate of P53 expression in patients with epithelial ovarian cancer were significantly positively correlated with the positive rate of Ki67 expression (r=0.872, P=0.000). Multivariate logistic regression analysis showed that infiltration, differentiation and pathological stage were the main factors affecting the positive rate of P53 and Ki67 expression (P<0.05). Conclusion: P53 and Ki67 in patients with epithelial ovarian cancer have high expression status, which is significantly correlated with the clinicopathological features of the patients. They can also affect each other and participate in the occurrence and development of epithelial ovarian cancer.