宫颈癌患者液基细胞学与组织学诊断的比较分析 仇

目的:通过对液基细胞学检测(TCT)与组织学活检的比较分析,探讨TCT出现漏诊的原因。方法:收集83例宫颈癌患者的宫颈活检组织蜡块和宫颈脱落细胞标本,组织蜡块行常规病理切片检查,脱落细胞标本进行TCT检测。结果:和组织病理学诊断结果比较,这些患者的TCT诊断漏诊18例。进行过抗HPV治疗的宫颈癌患者,其TCT漏诊率明显高于未治疗者(P<0.05)。结论:TCT在宫颈癌筛查中存在一定的漏诊,其产生的原因与癌细胞分化程度、宫颈糜烂程度、非诊断细胞的干扰、不当的采集方法及抗HPV治疗有关。

The Comparative Analysis of Liquid Based Cytology Diagnosis and Histological Diagnosis in 83 Cases of Cervical Squamous Cell Carcinoma

Objective: To explore the causes of the errors of liquid based cytology test,through a comparative analysis of liquid based cytology test and histology of biopsy.Methods: The paraffin blocks of cervical biopsies and the cervical cytology specimens of 83 cases of cervical carcinoma were collected,the paraffin blocks were for routine HE staining and histological diagnosis,the cytology specimens were dectected with liquid based cytology test and diagnosis.Results: Compared to histological diagnosis,the diagnosis in the liquid based cytology of these patients showed that 18 cases were missed diagnosed.The rate of misdiagosis of these patients who had been regularly anti-HPV treated was significantly higher than that of the others(P<0.05).Conclusion: There were some errors in liquid based cytology test in cervical cancer screening,the reasons associated with the cell differentiation,the degree of cervical erosion,the interference from non-diagnostic cells,the improper collection method and that the patients had been regularly anti-HPV treated.