米非司酮配伍米索前列醇与利凡诺在终止妊娠中的应用比较

目的:比较米非司酮配伍米索前列醇与利凡诺在终止妊娠中临床效果与安全性。方法:选取自愿终止妊娠者86例,随机分成观察组和对照组,每组各43例。观察组使用米非司酮配伍米索前列醇;对照组予以利凡诺行羊膜腔内穿刺注射。观察两组的引产过程、引产效果及可能出现的副作用。结果:观察组用药后宫缩发动时间、产程均短于对照组(P<0.01);观察组与对照组引产成功率分别为93.02%、86.05%,无统计学差异(P>0.05);但观察组24h内引产成功率显著高于对照组,而对照组24~48 h、48 h后引产成功率显著高于观察组(P<0.01)。观察组胎膜残留、产后2h内出血量、药物热、胃肠道反应、腹痛的发生率均低于对照组(P<0.05或P<0.01)。结论:米非司酮联合米索前列醇终止中期妊娠具有方法简单、宫缩发动快、产程短、损伤小、出血少等优点,优于利凡诺羊膜腔内穿刺注射。

Application Comparison on Termination of Pregnancy byMifepristone and Misoprostol with Rivanol

Objectives: To compare the clinical effect and safety of termination of pregnancy by Mifepristone and misoprostol with rivanol.Methods: 86 cases that terminated pregnancy voluntarily were selected,and they were randomly divided into observation group and control group,43 cases in each group.Patients in observation group were given mifepristone and misoprostol,yet patients in control group were given rivanol by amniotic cavity puncture injection.Labor process,labor effect and possible side effects in two groups were observed.Results: Uterine launch time and labor time after medicine of observation group were shorter than control group(P<0.01).The successful odinopoeia rate in observation group and control group were 93.02% and 86.05% respectively,yet there was no statistical dif-ference(P>0.05).The successful odinopoeia rate in 24h of observation group was higher than that in control group,while successful odinopoeia rate during 24~48 h and 48 h later in control group were higher than that in observation group(P<0.01).The rates of fetal membrane remain,postpartum bleeding in 2h,drug fever,abdominal pain and gastrointestinal reaction in observation group were lower than that in control group(P<0.05 or P<0.01).Conclusions: It has characteristics of simpler in method,quicker uterine launch,shorter labor time,little injury,less bleeding and other advantages of terminating mid-pregnancy by mifepristone combined with misoprostol,and it is better than amnion cavity puncture.