血清B7-H4水平对肝细胞癌的诊断及预后价值

目的:探讨肝细胞癌(HCC)患者血清B7-H4水平及其临床意义。方法:采用ELISA方法检测和比较116例HCC患者和60例健康对照人群的血清B7-H4水平,并分析血清B7-H4水平和HCC患者临床参数和生存情况的关系。结果:(1)HCC患者的血清B7-H4水平显著高于健康对照组(P0.001);(2)血清B7-H4水平与HCC患者血清AFP水平(r=0.653,P=0.012)和TNM分期(r=0.713,P=0.003)相关;(3)高血清B7-H4组HCC患者5年总体生存率较低血清B7-H4组显著降低(P=0.028);(4)血清B7-H4水平是HCC预后的独立预测因子(P=0.034)。结论:HCC患者的血清B7-H4水平显著上调,对于HCC的诊断及预后判断具有重要的参考意义。

Diagnostic and Prognostic Prediction Value of Serum B7-H4 Level for Hepatocellular Carcinoma

ABSTRACT Objective: To investigate the serum B7-H4 level of hepatocellular carcinoma (HCC) patients and its clinical signifi- cance. Methods: The serum B7-H4 level wase detected and compared in 116 cases of patients with HCC and 60 healthy controls by ELISA, and the relationships between serum B7-H4 levels and clinical parameters and the survival of HCC patients were analyzed. Results: HCC patients had significantly higher serum B7-H4 level as compared with the healthy controls(P<0.001); the serum B7-H4 level was correlated with the clinical parameters of HCC patients including the serum AFP level (r=0.653, P=0.012) and TNM stage(r=0.713, P=0.003); HCC patients with higher B7-H4 level group had a poorer 5-year overall survival rate (P=0.028). Moreover, the serum B7-H4 level was shown to be an independent prognostic factor for HCC(P=0.034). Conclusion: The serum B7-H4 level of HCC patients was signifi- cantly increased, which had important value for the diagnosis and prognosis of HCC.