眼睛发育与骨形成蛋白信号通路的关系

在早期胚胎发育过程中,眼睛是由起源于不同胚层的几个部分经过一系列的诱导作用以及时间和空间上的相互协调作用形成的复杂而又具有精确功能的器官。在眼睛的形成发育过程中,许多信号通路及其相关的调控因子发挥着重要作用。本文主要关注眼睛发育过程与骨形成蛋白(BMP)信号通路的关系,BMP信号的激活能够诱导晶状体的再生和CLT(角膜到晶状体的分化转移)进程,维持睫状体的功能,促进视网膜的发生,影响巩膜的重塑和泪腺的发育。很多眼部疾病的发生与BMP信号通路的调节紊乱密切相关,因此可以将BMP信号通路作为一个潜在的药物靶点来探究治疗眼部疾病的方法。本文就BMP信号通路对眼睛发育的影响作一综述。

Eye Development and BMP Signaling Pathway

ABSTRACT: The eye is a complex organ with precise function. In early embryonic development, eye is composed of several parts which are from the different germ layers through a series of induction and interaction. Multiple signaling pathways and their associated regulatory factors play important roles in the development of eyes. This review focuses on the relationship between eye development and BMP signaling pathway. The activation of BMP signal can induce the regeneration of the lens and the process of cornea to lens trans-dif- ferentiation (CLT). The activation of BMP signal can also maintain the function of the ciliary body, promote the development of retina, affect scleral remodeling and the development of lacrimal gland. Many ocular diseases are closely related to the dysregulation of BMP signaling pathway. Therefore, the regulation of BMP signal pathway can serve as a potential target for therapies of ocular diseases.