血β2微球蛋白水平在系统性红斑狼疮中的临床意义

目的：探讨系统性红斑狼疮（systemic lupus erythematosus，SLE）患者血β2-MG水平与疾病活动的相关性及其临床意义。方法：随机抽取2012年2月-2012年7月我科收治的62例SLE患者（SLE组）和同期在我院门诊体检的健康体检者40例（对照组），检测和比较两组血清β2-MG、自身抗体、补体水平，并对SLE患者进行SLEDAI评分，分析SLE患者血清β2-MG水平与自身抗体、补体水平和SLEDAI评分的相关性。结果：SLE组血β2-MG水平（3．11±0．40μg／mL）显著高于对照组（2．23±0．23μg/mL），差异有统计学意义（P〈0．05）；其中发生口腔溃疡、浆膜炎及蛋白尿的SLE患者的血β2-MG水平与无此三种表现的患者相比显著升高，差异有统计学意义（P〈0．05）。SLE患者的血β2-MG水平与抗ds—DAN抗体、SLEDAI均呈显著正相关（分别为r=0．289，r=0．361，P〈0．01），与C3呈负相关（r=-0．271，P〈0．05）。结论：SLE患者血β2-MG水平高于正常，可作为SLE疾病活动指标用于监测疾病活动。

The Clinical Significance of Beta2-microglobulin in Patients with Systemic Lupus Erythematosus

Objective： To investigate the clinical significance and relationship between serum beta2-microglobulin level and systemic lupus erythematosus （SLE） disease activity. Methods： Sixty-two patients with SLE were selected randomly in our hospital from Febr- uary 2012 to July 2012, and forty normal healthy controls were collected from outpatient department during the same time. The level of beta2-microglobulin, autoantibody and complement were investigated. Disease activity was assessed by SLEDAI. The correlation of serum beta2-microglobulin level with autoantibody, complement, SLEDAI of SLE were analyzed. Results： The beta2-microglobulin levels of the SLE patients （3.11±0.40μg/mL） were significantly higher than those of the normal controls （2.23± 0.23μg/mL, P〈0.05）. The beta2-microglobulin level of SLE patients with serositis, oral ulcer or lupus nephritis were significantly higher than those without serositis, oral ulcer or lupus nephritis, respectively. A positive correlation was found between the beta2-microglobulin level and anti-dsDNA antibody, SLE disease Activity Index （r=0.289, r=0.361, P〈0.01,respectively）. Serum beta2-microglobulin level was negatively correlated with complement 3 level. Conclusion： The level ofbeta2-microglobulin in SLE was higher than normal, which could help to monitor the disease activity of SLE.