胃癌病理特征改变与幽门螺旋杆菌感染的相关性分析

目的:探究HP感染与胃癌患者病理特征性改变的相关性。方法:选取我院消化内科收治并确诊为胃癌的患者50例,作为胃癌组;确诊为慢性浅表性胃炎的患者50例,作为胃炎组;选取同期进行健康体检未发现胃部异常的患者50例,作为对照组。对三组患者进行快速尿素氮试验、13C尿素呼气试验以及血清抗HPCag A等检查,比较患者HP感染等情况。结果:胃癌组及胃炎组患者HP感染阳性率及抗HPCag A阳性率显著高于对照组,且胃癌组较胃炎组明显增高,差异有统计学意义(P0.05)。胃癌早期及进展期患者HP感染率高于对照组,差异有统计学意义(P0.05)。胃癌组患者非贲门部HP感染率显著高于贲门部及对照组,差异有统计学意义(P0.05)。结论:HP感染是导致胃癌的主要因素,明确HP感染与胃癌病理分期及病变部位的相关性对胃癌的治疗及预防有重要的临床意义。

Analysis of Correlation between Pathologic Changes and HP Infection in Gastric Cancer

Objective:To explore the HP infection and gastric cancer patients with pathologic correlation characteristic change.Methods:To choose our digestive internal medicine and 50 cases of patients diagnosed with cancer of the stomach as gastric cancer group, 50 cases with chronic superficial gastritis as gastritis group, and 50 cases of patients, who were found with no abnormalities in stomach in physical examination during the same period, as control group. Urea nitrogen of the three groups of patients at high speed test, 13 curea breath test and serum anti HPCagA check, more patients with HP infection.Results:Patients with gastric cancer and gastritis positive rate of HP infection and anti HPCagA positive rate was significantly higher, and gastric cancer was significantly higher than the gastritis group, the difference was statistically significant (P <0.05). Early and advanced gastric cancer patients with HP infection rate higher, and the difference was statistically significant (P <0.05). Non-cardia gastric cancer patients HP infection rate was significantly higher than the cardia and control group, the difference was statistically significant (P <0.05).Conclusion:HP infection is the leading cause of cancer of the stomach pathogenic factors, clear HP infection and gastric cancer pathological staging and the correlation of the lesion site, which is important for prevention and treatment of gastric cancer in clinical practice.