| 食管鳞癌组织中的神经纤维分布 |
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| 引用本文： | 同李平 袁世发,丰帆 杨建军 张洪伟.食管鳞癌组织中的神经纤维分布[J].现代生物医学进展,2011,11(14):2635-2638. |
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| 作者姓名： | 同李平 袁世发 丰帆 杨建军 张洪伟 |
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| 作者单位： | 1. 第四军医大学附属西京消化病医院消化一科,肿瘤生物学国家重点实验室,陕西西安710015
2. 第四军医大学附属西京消化病医院消化一科,肿瘤生物学国家重点实验室,陕西西安710015;河北省武警总队医院普外科,河北石家庄050018 |
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| 摘 要： | 目的:探讨食管鳞癌组织中神经纤维的分布情况.方法:应用免疫组化ABC法,探查手术切除的食管鳞癌组织里S100及GAP-43阳性神经纤维的分布情况,并分析其与患者临床病理参数的关系.结果:相对于正常组织,食管鳞癌组织中存在相当数量的S100及GAP-43阳性神经纤维(束)不规则地分布于肿瘤细胞之间,且S100阳性纤维密度大于GAP-43阳性纤维密度;统计分析显示肿瘤组织中纤维密度与患者的肿瘤大小、淋巴结转移相关.结论:食管鳞癌组织中确实存在神经纤维分布,并对肿瘤发展起一定作用.
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| 关 键 词： | 食管鳞癌 神经纤维 GAP-43 免疫组化 |
Nerve Fiber Distribution in Esophageal Squamous Cell Carcinoma |
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| TONG Li-ping,YUAN Shi-f,FENG Fan,YANG Jian-jun,ZHANG Hong-wei.Nerve Fiber Distribution in Esophageal Squamous Cell Carcinoma[J].Progress in Modern Biomedicine,2011,11(14):2635-2638. |
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| Authors: | TONG Li-ping YUAN Shi-f FENG Fan YANG Jian-jun ZHANG Hong-wei |
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| Institution: | TONG Li-ping1,YUAN Shi-fa1,2,FENG Fan1,YANG Jian-jun1,ZHANG Hong-wei(1 Department of Gastrointestinal Surgery,Xijing Hospital of Digestive Diseases,State Key Laboratory of Cancer Biology,the Fourth Military Medical University,Xi'an 710032,China,2 Department of General Surgery,Hospital of Hebei Province Corps of Chinese Armed Police Force,Shijiazhuang,050018,China.) |
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| Abstract: | Objective: The aim of this study was to investigate the arrangement and pathological significance of immunoreactive nerve fibers in the tumor mass of human esophageal squmous cell carcinoma(ESCC).Methods: Frozen sections were processed for im-munohistochemistry staining to detect the distribution of the intratumoral nerves visualized by antibodies against S100 and growth associ-ated protein 43(GAP-43).Results: The microscopic observations revealed plenty of S100 positive fibers and relatively minor GAP-43 p... |
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| Keywords: | ESCC Nerve fiber GAP-43 Immunohistochemistry |
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