不同病情冠心病患者血清心型脂肪酸结合蛋白与颈动脉内膜中层厚度的关系分析

目的:探讨不同病情冠心病患者血清心型脂肪酸结合蛋白(H-FABP)与颈动脉内膜中层厚度(IMT)的关系。方法:选择内蒙古科技大学包头医学院第一附属医院老年科收治的冠心病患者60例,其中稳定型心绞痛(SAP)和急性冠脉综合征(ACS)各30例,根据冠状动脉病变支数将患者分为单支病变组19例、双支病变组19例和多支病变组22例;根据患者冠状动脉血管狭窄程度分为轻度病变组22例、中度病变组17例和重度病变组21例,选择同期健康体检者30例作为对照组。比较各组颈动脉IMT及血清H-FABP水平,并分析其相关性。结果:ACS组颈动脉IMT及血清H-FABP水平显著高于SAP组和对照组,SAP组颈动脉IMT及血清H-FABP水平显著高于对照组(P<0.05)。不同冠状动脉病变支数、病变程度冠心病患者颈动脉IMT及血清H-FABP水平整体比较差异有统计学意义(P<0.05),多支病变组和双支病变组血清H-FABP水平比较无统计学意义(P>0.05)。Spearman相关分析显示,冠心病患者血清H-FABP水平与颈动脉IMT呈正相关(r=0.754,P<0.05)。结论:冠心病患者血清H-FABP水平与颈动脉IMT异常升高,其水平随冠状动脉病变程度加重而升高,且两者呈正相关。

Analysis of the Relationship between Serum Heart Type Fatty Acid Binding Protei and Carotid Intima-media Thickness in Patients with Different Conditions of Coronary Heart Disease

ABSTRACT Objective: To investigate the relationship between serum heart type fatty acid binding protei (H-FABP) and carotid intima-media thickness in patients with different conditions of coronary heart disease. Methods: 60 patients with coronary heart disease who were treated in Geriatrics Department of The First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology were selected, the paitients included 30 patients with stable angina pectoris (SAP) and 30 patients with acute coronary syndrome (ACS), they were divided into single-vessel lesion group (19 cases), double-vessel lesion group (19 cases) and multi-vessel lesion group (22 cases) according to the number of coronary artery lesions. The patients were divided into mild lesion group (22 cases), moderate lesion group (17 cases) and severe lesion group (21 cases) according to the degree of coronary artery stenosis. 30 healthy people in the same period were selected as control group. The carotid IMT and serum level of H-FABP were compared in each group, and their correlation was analyzed. Results: The carotid IMT and serum level of H-FABP in the ACS group were significantly higher than those in the SAP group and the control group. The carotid IMT and serum level of H-FABP in the SAP group were significantly higher than those in the control group(P<0.05). The carotid IMT and serum level of H-FABP in patients with different coronary artery lesions and degree of coronary artery disease had statistical significance(P<0.05). There was no significant difference in the level of serum H-FABP between patients with multi-vessel lesions and patients with double vessel lesions(P>0.05). Spearman correlation analysis showed that serum level of H-FABP was positively correlated with carotid IMT in patients with coronary heart disease (r=0.754, P<0.05). Conclusion: The level of serum H-FABP and carotid IMT in patients with coronary heart disease increased abnormally, and its level is increased with the degree of coronary artery disease, and there is a positive correlation between them.