桂枝茯苓丸联合米非司酮对子宫肌瘤患者血液流变学及血红蛋白、人附睾蛋白4的影响

目的:研究桂枝茯苓丸联合米非司酮对子宫肌瘤患者血液流变学及血红蛋白(Hb)、人附睾蛋白4(HE4)的影响。方法:选取2016年3月到2017年5月西安交通大学医学院附属三二〇一医院收治的172例子宫肌瘤患者,随机分为观察组(n=86)和对照组(n=86)。对照组给予米非司酮治疗,观察组在对照组的基础上联合桂枝茯苓丸治疗,对比两组疗效,比较两组治疗前及治疗后的Hb、HE4、肌瘤体积、血液流变学指标以及不良反应。结果:观察组的总有效率为97.67%,高于对照组的89.53%(P0.05);治疗后,两组的Hb水平均明显高于治疗前,且观察组高于对照组(P0.05),两组的HE4水平均低于治疗前,观察组低于对照组(P0.05),肌瘤体积均小于治疗前,且观察组小于对照组(P0.05);治疗后两组的全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)及血小板聚集率(PAR)均低于治疗前,且观察组低于对照组(P0.05);观察组、对照组不良反应的总发生率分别为13.95%、10.47%,差异无统计学意义(P0.05)。结论:桂枝茯苓丸联合米非司酮治疗子宫肌瘤患者的疗效较好,可改善其血液流变学及Hb、HE4等指标水平,安全性较好,值得推广。

Effects of Guizhi Fuling Bolus Combined with Mifepristone on Hemorheology, Hemoglobin and Human Epididymis Protein 4 in Patients with Hysteromyoma

ABSTRACT Objective: To study the effects of Guizhi Fuling bolus combine with mifepristone on hemorheology, hemoglobin (Hb) and human epididymis protein 4 (HE4) in patients with hysteromyoma. Methods: 172 patients with hysteromyoma treated in 3201 Hospital Affiliated to Medical College of Xi''an Jiaotong University from March 2016 to May 2017 were selected, the patients were randomly divided into the observation group (n=86) and the control group (n=86). The control group was treated with mifepristone, the observation group was treated with Guizhi Fuling bolus on the basis of the control group, the efficacy was compared between the two groups after 3 months treatment, the Hb, HE4, myoma volume, blood rheology indexes were compared between the two groups before treatment and after 3 months treatment, the adverse reaction was compared between the two groups. Results: The total effective rate of the observation group was 97.67%, which was higher than 89.53% of the control group (P<0.05). After treatment, the levels of Hb in both groups were significantly higher than before treatment, which in the observation group was higher than the control group (P<0.05). The level of HE4 in both groups was lower than that before treatment, the observation group was lower than that in the control group (P<0.05), and the fibroid volume was smaller than that before treatment, and the observation group was smaller than that in the control group (P<0.05). After treatment, the total blood viscosity (HBV), total blood viscosity (LBV), plasma viscosity (PV) and platelet aggregation rate (PAR) of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). The total incidence of adverse reactions in the observation group and control group were 13.95% and 10.47%, which was no significant difference (P>0.05). Conclusion: Guizhi poring bolus combined with mifepristone is effective in treating uterine fibroids, which can improve the level of hemorheology, Hb, HE4 and other indicators, with good safety and worth popularizing.