血清同型半胱氨酸、高敏C反应蛋白及肱踝脉搏波传导速度与冠心病患者冠脉病变程度的相关性研究

目的:探讨血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)及肱踝脉搏波传导速度(baPWV)与冠心病患者冠脉病变程度的相关性。方法:选取2015年6月-2017年10月期间承德医学院附属医院收治的疑似冠心病的患者324例为研究对象,根据冠状动脉造影结果分为冠心病组213例与非冠心病组111例,根据不同冠脉病变程度将冠心病组分为单支病变组87例,双支病变组74例,多支病变组52例,检测并对比所有患者血清Hcy、hs-CRP水平及baPWV值,分析Hcy、hs-CRP水平及baPWV值与冠心病患者冠脉病变程度相关性。结果:冠心病组患者血清Hcy、hs-CRP水平及baPWV值较非冠心病组升高(P0.05)。冠心病组不同冠脉病变程度患者血清Hcy、hs-CRP水平及baPWV值整体比较差异有统计学意义(P0.05),多支病变组与双支病变组患者血清Hcy、hs-CRP水平及baPWV值高于单支病变组,且多支病变组高于双支病变组,差异有统计学意义(P0.05)。经Pearson相关性分析显示,Hcy、hs-CRP及baPWV均与冠心病患者冠脉病变程度呈正相关(P0.05)。结论:冠心病患者血清Hcy、hs-CRP水平及baPWV值高于非冠心病者,且血清Hcy、hs-CRP水平及baPWV值随着冠心病患者冠脉病变程度的加重而升高,与冠脉病变程度呈正相关。

Correlation Study of Serum Homocysteine, High Sensitive C Reactive Protein and Brachial Ankle pulse Wave Velocity to Degree of Coronary Artery Disease in Patients with Coronary Heart Disease

ABSTRACT Objective: To investigate the correlation between serum homocysteine (Hcy), high sensitivity C reactive protein (hs-CRP), brachial ankle pulse wave velocity (baPWV) and degree of coronary artery lesion in patients with coronary heart disease. Methods: 324 patients with suspected coronary heart disease who were treated in Affiliated Hospital of Chengde Medical College from June 2015 to October 2017 were selected as the research subjects, according to the results of coronary angiography, the patients were divided into coronary heart disease group with 213 cases and non coronary heart disease group with 111 cases. According to the different degree of coronary artery disease, coronary heart disease group was divided into single branch lesion group with 87 cases, double branch lesion group with 74 cases, multiple branch lesion group with 52 cases. The levels of serum Hcy, hs-CRP and baPWV value were measured and compared in all patients, the correlation between Hcy, hs-CRP levels, baPWV value and the degree of coronary artery disease in patients with coronary heart disease was analysed. Results: The levels of serum Hcy, hs-CRP and baPWV value of patients in coronary heart disease group were higher than those in non coronary heart disease group (P<0.05). There was significant difference in overall comparison of serum Hcy, hs-CRP levels and baPWV value in patients with different degree of coronary artery disease in coronary artery disease group(P<0.05), the levels of serum Hcy, hs-CRP and baPWV value of patients in multiple branch lesion group and double branch lesion group were higher than those in single branch lesion group, and multiple branch lesion group was higher than that of the double branch lesion group, the difference was statistically significant (P<0.05). The Pearson correlation analysis showed that Hcy, hs-CRP and baPWV were positively correlated with the degree of coronary artery disease in patients with coronary heart disease (P<0.05). Conclusion: The levels of serum Hcy, hs-CRP and baPWV value in patients with coronary heart disease are significantly higher than those of non coronary heart disease, and the levels of Hcy, hs-CRP and baPWV value are increased with the severity of degree of coronary artery disease in patients with coronary heart disease, which are positively correlated with the severity of degree of coronary artery disease.