非小细胞肺癌EGFR 表达与18F-FDG-PET SUVmax 值 的相关性研究

目的:探讨非小细胞肺癌组织中EGFR蛋白在的表达与PET-CT检测的SUVmax的相关性。方法:临床收集30例非小细胞肺癌患者,每一病例首先行PET-CT检查,然后行CT导引下活检穿刺,同一病灶取2个穿刺部位,分别为肿瘤组织内SUVmax值2.5-5区域及SUVmax>5区域,采用免疫组化方法检测检测30例非小细胞肺癌肿瘤内部不同部位EGFR表达。结果:EGFR蛋白表达、SUVmax值在不同年龄、性别、病理类型中表达的差异无统计学意义(P均>0.05)。EGFR蛋白表达、SUVmax值在不同的肿瘤直径、临床分期组表达差异有统计学意义(P均<0.05)。NSCLC肿块SUVmax值与组织EGFR表达呈显著正相关(P<0.05)。结论:NSCLC组织SUV值与组织EGFR表达有显著相关性,可以为非小细胞肺癌的放疗提供指导。

Correlation Between the Expression of EGFR and 18F-FDG-PET SUVmax in Non-small Cell Lung Cancer

Objective: To investigate the relationship between the expression of EGFR (epidermal growth factor receptor) and SUVmax (standard uptake value maximum) in non-small cell lung cancer(NSCLC).Methods: 30 patients with non-small cell lung cancer and undergonePET-CT scan were registered.The two areas with different SUV max (2.5-5 vs.5 or more) of patients'tumor tissue were taken by needle puncture biopsy under the CT guidance.Expression of EGFR of the two areas were detected and analyzed by immunohistochemical staining.Results:There was no statistical difference for the expression of EGFR and SUVmax in age,gender, Pathology and differentiation (P>0.05).The expression of EGFR and SUVmax has respectively Significant difference in tumor size and clinical Stage (P<0.05).The SUVmax was correlated positively with the expression of EGFR (r=0.836,P<0.05).Conclusions:The SUVmax is correlated positively with EGFR expression in NSCLC,which Can provide the guidance for radiotherapy.