过敏性紫癜性肾炎肾组织中KIM-1的表达与临床意义

目的:探讨过敏性紫癜性肾炎肾组织中肾损伤分子1(kidney injury molecule 1,KIM-1)的表达与临床意义。方法:选择2015年4月到2018年1月在我院诊治的过敏性紫癜性肾炎患者150例作为研究对象,采用免疫组化法检测患者肾组织中KIM-1表达,采用半定量评分系统进行肾脏病理损害评分,并对二者进行相关性分析。结果:肾炎组织与肾旁组织的KIM-1相对表达量分别为(9.28±1.38)和(2.74±1.30),肾炎组织中KIM-1的表达显著高于肾旁组织(P=0.000);肾炎组织的毛细血管外肾小球活动、系膜增殖、内皮增殖、肾间质炎症、肾小球慢性化、肾小管间质慢性化指数评分均显著高于肾旁组织(P0.05);肾组织KIM-1表达量与肾小球慢性化指数、肾间质炎症指数、肾小管间质慢性化指数均呈显著正相关性(P0.05)。结论:过敏性紫癜性肾炎组织中KIM-1呈高表达,可能作为评估肾脏病理病变程度的参考指标。

Expression and Clinical Significance of KIM-1 in the Henoch Schonlein Purpura Nephritis

ABSTRACT Objective: To investigate the expression and clinical significance of kidney injury molecule 1 (KIM-1) in the renal tissue of Henoch-Schonlein purpura nephritis (HSPN). Methods: 150 patients with HSPN who were treated in our hospital from April 2015 to January 2018 were selected as the research objects. The expression of KIM-1 in the renal tissue was detected by immunohistochemical method. The renal pathological damage score was evaluated by semi-quantitative scoring system. Results: The relative expression of KIM-1 in the nephritic tissue and paranephritic tissue were (9.28±1.38) and (2.74±1.30), respectively. The expression of KIM-1 in the nephritic tissue was significantly higher than that in the paranephritic tissue (P=0.000). The scores of extracapillary glomerular activity, mesangial proliferation, endothelial proliferation, interstitial inflammation, glomerular chronicity and tubulointerstitial chronicity index in the nephritic tissue were significantly higher than those in the paranephritic tissue (P<0.05). The expression of KIM-1 was positively correlated with the glomerular chronic index, renal interstitial inflammatory index and tubulointerstitial chronic index (P<0.05). Conclusion: KIM-1 is highly expressed in the HSPN tissue, which may serve as a reference index for evaluating the degree of renal pathological changes.