IL-6 和IL-23在溃疡性结肠炎患者肠粘膜中的表达及意义

目的:研究溃疡性结肠炎患者炎症粘膜中IL-6及IL-23的表达及其临床意义。方法:选取2013年4月到2014年4月我院收治的溃疡性结肠炎患者60例,根据Sutherland疾病活动指数分为轻度组(11例)、中度组(19例)、重度组(14例)、缓解期组(16例),另选健康志愿者20名为对照组。分别检测各组粘膜细胞因子IL-6及IL-23的表达水平。结果:轻度组、中度组及重度组患者的IL-6和IL-23表达水平逐渐增高,显著高于缓解期组和对照组,差异有统计学意义(P<0.05);缓解期组患者IL-23水平显著高于对照组,差异有统计学意义(P<0.05);而IL-6表达与对照组比较无显著差异(P>0.05)。结论:IL-6和IL-23在溃疡性结肠炎的发生与发展中起重要作用,其表达能够反应溃疡性结肠炎的炎性程度。

The Expression of Inflammatory Factor in Inflamed Mucosa of Patients with Ulcerative Colitis and its Clinical Significance

Objective:To investigate the expression of IL-6 and IL-23 in inflammatory mucosa of patients with ulcerative colitis and its clinical significance.Methods:A total of 60 patients with ulcerative colitis who were treated in our hospital between April 2013 and 2014 were selected. According to the Sutherland disease activity index, the patients were divided into the slight group (11 cases), the moderate group (19 cases), the severe group (14 cases) and the remission group (16 cases). And another 20 healthy people were chosen as the control group. Then the expressions of mucosal cytokines IL-6 and IL-23 were detected and compared.Results:The expressions of IL-6 and IL-23 in slight group, moderate group and severe active group increased significantly with statistical differences (P<0.05); the expressions of IL-6 and IL-23 in the three group were significantly higher than those of the patients in the remission group and the control group (P<0.05); the expression of IL-23 in the remission group was higher than that of the control group (P<0.05), but there was no statistically significant difference about the expression of IL-6 between the remission group and the control group (P>0.05).Conclusion:IL-6 and IL-23 play the important roles in the occurrence and development of ulcerative colitis, and the expressions of IL-6 and IL-23 could reflect the activity of the disease.