非酒精性脂肪性肝病的研究进展

非酒精性脂肪性肝病(NAFLD)在西方国家较为常见,近年来在我国的发病呈上升趋势,且发展逐渐低龄化。非酒精性脂肪性肝病患者可能因持续性肝损伤而导致纤维化进展,可与慢性病毒性肝炎和酒精性肝病一样发展到终末期肝硬化,并出现肝硬化严重并发症,也有可能发展成肝癌,最终需要肝移植治疗。它严重危害人类的健康,影响人类的生活及生存质量。多因素的发病机制使其愈来愈被人们所重视,研究和了解非酒精性脂肪性肝病的流行病学、发病机制、诊断及治疗方法,对人类非常重要,如果在疾病的早期,也就是单纯性脂肪肝阶段就对疾病进行干预,这样可以取得很好的治疗效果,NAFLD是人类在本世纪需要面对的疾病之一,因此研究它的发病机制及治疗方法是非常必要的。

Recent Progress in Research of Nonalcoholic Fattyliver Disease

Non- alcoholic fatty liver disease (NAFLD) is a common disease in Western countries. In recent years, the incidence is rising in our country, and gradually develop at a younger age. Non- alcoholic fatty liver disease may be due to liver damage caused by persistent fibrosis, with chronic viral hepatitis and alcoholic liver disease as development to end-stage cirrhosis and severe complications of cirrhosis, it may develop into cancer, ultimately require liver transplantation. It seriously endanger human health, affecting the quality of human life and survival. Multifactorial pathogenesis makes it increasingly been emphasized, It is important to study and understand the non-alcoholic fatty liver disease epidemiology, pathogenesis, diagnosis and treatment If intervention was performed in the early stage, that is, the stage of simple fatty liver, then patients would achieve a good therapeutic effect. NAFLD is one of the diseases that human need to face in this century, so the research of its pathogenesis and treatment method is very necessary.