老年代谢综合征患者颈动脉内膜中层厚度与血管内皮功能及血管粘附因子-1的相关性

目的:探讨老年代谢综合征(MS)患者颈动脉内膜中层厚度(IMT)与血管内皮功能及血管粘附因子-1(VCAM-1)的相关性。方法:选取2013年1月~2014年10月我院收治的50例MS患者分为老年组(n=25)和中青年组(n=25),又根据IMT分为正常组和增厚组两个亚组。比较老年组和中青年组患者的临床资料,采用放射免疫分析法检测所有患者内皮素-1(ET-1)水平,采用分光光度计间接比色法检测一氧化氮(NO)水平,采用ELISA法检测VCAM-1水平,采用超声诊断仪检测IMT。结果:老年MS组和中青年MS组临床资料比较,差异均无统计学意义(均P0.05);MS患者IMT增厚组的NO水平均低于IMT正常组,而ET-1和VCAM-1水平均高于IMT正常组,比较差异有统计学意义(均P0.05)。IMT增厚组间比较,老年MS组的NO水平低于中青年MS组,VCAM-1水平高于中青年MS组,比较差异均有统计学意义(P0.05);老年MS组和中青年MS组的IMT与NO水平呈负相关(r=-0.415,-0.411;P=0.043,0.049),与ET-1和VCAM-1水平呈正相关(r=0.585,0.576;P=0.030,0.036;r=0.547,0.552;P=0.033,0.031)。结论:血管内皮功能障碍和动脉粥样硬化等多重因素促进了MS患者IMT增厚中病理过程的发生和发展。

Correlation between Carotid Artery Intima Media Thickness and Vascular Endothelial Function and Vascular Adhesion Factor-1 in Elderly Patients with Metabolic Syndrome

ABSTRACT Objective: To investigate the correlation between carotid artery intima media thickness(IMT)and vascular endothelial function and vascular adhesion factor-1(VCAM-1)in elderly patients with metabolic syndrome(MS). Methods: Selected 50 cases of patients with MS in our hospital from October 2014 to January 2013 were divided into the elderly group(n=25)and young and middle-aged group(n=25), and were divided into normal group and the thickening group according to the IMT. Compare the clinical data of the elderly group and the young and middle-aged group, detected the level of endothelin-1(ET-1)in all patients by the radioimmunoassay, detected the level of nitric oxide(NO)by spectrophotometer with indirect colorimetric method, detected the level of VCAM-1 by ELISA method, Detected the IMT by ultrasonic diagnostic apparatus. Comparison and correlation analysis between groups on the above indicators. Results: There was no significant difference in the clinical data between elderly MS group and young and middle aged MS group(P>0.05); The levels of NO in the MS patients with IMT thickening group were lower than those in the IMT normal group, while the levels of ET-1 and VCAM-1 were higher than those in the IMT normal group,the differences were statistically significant(P<0.05); Comparison of IMT thickening group, the level of NO in the elderly MS group was lower than that in young and middle aged MS group, the level of VCAM-1 was higher than that in the young and middle aged MS group, and the differences were statistically significant(P<0.05); IMT was negatively correlated with the level of NO in the elderly MS group and young and middle aged MS group(r=-0.415, -0.411; P=0.043, 0.049), and were positively correlated with the levels of ET-1 and VCAM-1(r=0.585, 0.576; P=0.030, 0.036; r=0.547, 0.552; P=0.033, 0.031). Conclusion: Multiple factors, such as vascular endothelial dysfunction and atherosclerosis,promote the occurrence and development of IMT thickening in MS patients.