细胞外基质Matrilin-4的研究进展

Matrilin-4是非胶原性细胞外基质蛋白家族的一员,广泛分布于疏松和致密结缔组织、皮肤和消化道上皮组织、骨、软骨、血管壁和神经系统。因其广泛的分布及特异性表达,使其成为一些疾病的致病因子,多种细胞信号途经可通过调节matrilin-4的表达调控细胞外基质的性能,进而影响疾病的发生、发展。随着近年来对matrilin-4的深入研究,可能为某些疾病的治疗提供新的思路。本文总结了matrilin-4在相关领域的最新研究进展,并对matrilin-4的基因结构,与家族其他成员的关系以及在疾病中的作用作一综述。

Research Progress on Extracellular Matrix Matrilin-4

ABSTRACT: Matrilin-4 is a member of the non-collagenous extracellular matrix protein family, and it widely distributes in loose and dense connective tissues, skin and digestive tract epithelial tissues, bone, cartilage, blood vessel wall and nervous system. Because of its widely distribution and specific expression, its mutations can contribute to multiple diseases. Many signaling pathways modulate the extracellular matrix indirectly by regulating the expression of matrilin-4. With the further research of matrilin-4 in recent years, some new ideas for the treatment of some diseases may be provided. This paper summarizes the latest research progress of matrilin-4 in related fields, and reviews the structure of matrilin-4, the relationship between other family members and the role of matrilin-4 in disease.