寻常型银屑病患者血清肽基脯氨酰顺反异构酶1、摄食抑制因子1、血管生成素2的变化及临床意义

摘要 目的：观察寻常型银屑病患者血清肽基脯氨酰顺反异构酶1（Pin1）、摄食抑制因子1（nesfatin-1）、血管生成素2（ANGPT2）水平的变化，并探讨分析其临床意义。方法：选择我院2019年5月～2021年5月收治的寻常型银屑病患者98例，分别比较不同疾病严重程度和不同疾病分期患者的血清Pin1、nesfatin-1、ANGPT2水平，采用Pearson检验分析血清Pin1、nesfatin-1、ANGPT2水平与皮损面积及严重程度指数（PASI）评分的相关性，采用光疗仪对患者进行治疗，比较治疗前后血清Pin1、nesfatin-1、ANGPT2水平变化。结果：重度组和中度组患者的Pin1、ANGPT2水平均高于轻度组，且重度组高于中度组（P＜0.05）；重度组和中度组患者的nesfatin-1水平均低于轻度组，且重度组低于中度组（P＜0.05）。进行期组患者的Pin1、ANGPT2水平高于静止期组和退行期组患者，而nesfatin-1水平低于静止期组与退行期组患者（P＜0.05）；静止期组与退行期组之间上述各指标比较差异无统计学意义（P＞0.05）。Pearson相关性分析结果显示，寻常型银屑病患者的血清Pin1、ANGPT2水平与PASI评分呈正相关，而nesfatin-1水平与PASI评分呈负相关（P＜0.05）。治疗后，寻常型银屑病患者的血清Pin1、ANGPT2水平明显降低，nesfatin-1水平则明显升高（P＜0.05）。结论：寻常型银屑病患者的病情越重，血清Pin1、ANGPT2水平越高，而nesfatin-1水平越低，且三者对患者疗效有一定评估价值。

Changes and Clinical Significance of Serum Peptidyl-prolyl Cis-transisomerase NIMA-interacting1, Nesfatin-1 and Angiopoietin-2 in Patients with Psoriasis Vulgaris

ABSTRACT Objective: To observe the changes of serum peptidyl-prolyl cis-transisomeraseNIMA-interacting1 (Pin1), nesfatin-1 (nesfatin-1) and angiopoietin-2 (ANGPT2) in patients with psoriasis vulgaris, and to explore and analyze their clinical significance. Methods: 98 patients with psoriasis vulgaris who were treated in our hospital from May 2019 to May 2021 were selected. The levels of serum Pin1, nesfatin-1 and ANGPT2 in patients with different disease grades and different disease stages were compared. Pearson linear correlation was used to analyze the correlation between the levels of serum Pin1, nesfatin-1 and ANGPT2 and Index of lesions area and severity (PASI) score. The patients were treated with phototherapy instrument. The changes of levels of serum Pin1, nesfatin-1 and ANGPT2 before and after treatment were compared. Results: The levels of Pin1 and ANGPT2 in severe group and moderate group were higher than those in mild group, and those in severe group were higher than those in moderate group (P<0.05). The level of nesfatin-1 in severe group and moderate group was lower than that in mild group, and that in severe group was lower than that in moderate group (P<0.05). The levels of Pin1 and ANGPT2 in progressive stage group were higher than those in quiescent stage group and degenerative stage group, while the level of nesfatin-1 was lower than that in quiescent stage group and degenerative stage group(P<0.05). There was no significant difference in the above indexes between quiescent stage group and degenerative stage group(P>0.05). Pearson correlation analysis showed that the levels of serum Pin1 and ANGPT2 in patients with psoriasis vulgaris were positively correlated with PASI score, while the level of nesfatin-1 was negatively correlated with PASI score (P<0.05). After treatment, the levels of serum Pin1 and ANGPT2 in patients with psoriasis vulgaris decreased significantly, while the level of nesfatin-1 increased significantly(P<0.05). Conclusion: The more severe the condition of patients with psoriasis vulgaris, the higher the levels of serum Pin1 and ANGPT2, and the lower the level of nesfatin-1, and they have a certain evaluation value for the curative effect of patients.