| 抗缺氧中药研究进展 |
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| 引用本文： | 王维刚,阳志强,李晓琳,李茂星.抗缺氧中药研究进展[J].天然产物研究与开发,2022(2). |
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| 作者姓名： | 王维刚 阳志强 李晓琳 李茂星 |
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| 作者单位： | 甘肃中医药大学药学院;联勤保障部队第九四〇医院临床药学科;甘肃省高原药学行业技术中心;西北民族大学化工学院 |
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| 基金项目： | 甘肃省重点研发项目(20YF3FA035);拔尖培育项目(2021yxky001);甘肃省卫生行业科研计划(GSWSKY2020-41);“新冠肺炎(COVID-19)”应急医学科研项目(20yjky018)。 |
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| 摘 要： | 氧气是生命活动必不可少的物质基础,由高原低压低氧及呼吸系统疾病、心血管疾病等内外界因素引起的缺氧可导致线粒体损伤,能量代谢紊乱,氧化应激,炎症爆发等一系列反应,进而损伤机体。研发安全、有效的治疗药物显得尤为重要。近年来大量研究表明,中药在抗缺氧方面有巨大的潜力。本文归纳总结了抗缺氧中药单体化合物、中药提取物及中药复方的研究进展,为抗缺氧中药的深入研究和开发提供思路,为其临床应用提供参考。
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| 关 键 词： | 抗缺氧 缺氧损伤 单体化合物 中药提取物 中药复方 |
Research progress of anti-hypoxic Chinese medicine |
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| WANG Wei-gang,YANG Zhi-qiang,LI Xiao-lin,LI Mao-xing.Research progress of anti-hypoxic Chinese medicine[J].Natural Product Research and Development,2022(2). |
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| Authors: | WANG Wei-gang YANG Zhi-qiang LI Xiao-lin LI Mao-xing |
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| Institution: | (College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Clinical Pharmacy,the 940th Hospital of Joint Logistic Support Force of PLA;Gansu Plateau Pharmaceutical Technology Center,Lanzhou 730050,China;Institute of Chemical Technology,Northwest Minzu University,Lanzhou 730030,China) |
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| Abstract: | Oxygen is an essential material basis for life activities.Hypobaric hypoxia in high altitude, respiratory diseases, cardiovascular diseases and other internal and external factors can lead to mitochondrial damage, energy metabolism disorder, oxidative stress, inflammation and a series of reactions, and damage the body.It is particularly important to develop safe and effective therapeutic drugs.In recent years, a large number of studies have shown that Chinese medicine has great potential in anti-hypoxia.This paper summarizes the research progress of anti-hypoxic monomeric compound, extracts and compounds of Chinese medicine, providing ideas for the in-depth study and development of anti-hypoxia Chinese medicine, and providing reference for its clinical application. |
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| Keywords: | anti-hypoxia hypoxia injury monomeric compound Chinese medicine extracts Chinese medicine compounds |
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