| DNA动力学柔性的统计力学模型 |
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| 引用本文： | 蔡禄,罗辽复.DNA动力学柔性的统计力学模型[J].生物物理学报,2001,17(2):311-317. |
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| 作者姓名： | 蔡禄 罗辽复 |
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| 作者单位： | 1. 清华大学生命科学与技术系,;包头钢铁学院生物与化学工程系,
2. 内蒙古大学物理系, |
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| 基金项目： | 内蒙古自然科学基金资助课题(20001302),包头钢铁学院科研基金资助课题 |
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| 摘 要： | 考虑碱基对之间的非紧邻相互作用、涨落的序列依赖效应和非对称涨落，提出了DNA构象的统计力学模型，给出了DNA柔性的新定义。作为模型的应用，对12种三核苷酸重复序列的动力学柔性作了预测。理论预测与其它方法得到的结论比较，有很好的一致性。对模型和结论的理论意义作了讨论。
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| 关 键 词： | DNA 柔性 统计力学模型 |
| 文章编号： | 1000-6737(2001)02-0311-07 |
| 修稿时间： | 2000年9月5日 |
A STATISTICAL-MECHANICAL MODEL OF DNA FLEXIBILITY |
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| CAI Lu,LUO Liao-fu.A STATISTICAL-MECHANICAL MODEL OF DNA FLEXIBILITY[J].Acta Biophysica Sinica,2001,17(2):311-317. |
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| Authors: | CAI Lu LUO Liao-fu |
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| Institution: | CAI Lu1,3,LUO Liao-fu2 |
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| Abstract: | A statistical-mechanical model taking account of non-neighboring interactions between base-pairs, sequence-dependent symmetric twisting, tilting, sliding fluctuations and asymmetric rolling fluctuations was proposed to predict DNA conformation. A new definition of DNA flexibility was also given. As an application, the flexibilities of 12 triplet repeat sequences were predicted. The predictions on DNA flexibility were compared with the corresponding data calculated with other methods. Agreement is obtained and good. The biological implications were discussed. |
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| Keywords: | DNA Flexibility Statistical mechanical model |
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