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| 小鼠增龄过程中耳蜗MeCP2的变化 | |
| 引用本文： | 蒋腊梅,张勇,葛圣雷,伍伟景.小鼠增龄过程中耳蜗MeCP2的变化[J].激光生物学报,2011,20(1):74-77. |
| 作者姓名： | 蒋腊梅 张勇 葛圣雷 伍伟景 |
| 作者单位： | 1. 湖南师范大学医学院,湖南,长沙,410006;中南大学湘雅二医院耳鼻咽喉-头颈外科,湖南,长沙,410011 2. 湖南师范大学医学院,湖南,长沙,410006 3. 中南大学湘雅二医院耳鼻咽喉-头颈外科,湖南,长沙,410011 |
| 基金项目： | 湖南省科技厅科学研究项目，国家自然科学基金，湖南师范大学博士科研启动计划项目 |
| 摘 要： | 在对不同月龄BALB/c小鼠听功能和耳蜗形态学研究的基础上,应用免疫组化技术,检测不同月龄组(3,6,12,18月龄)小鼠耳蜗组织中MeCP2的表达与分布情况,初步探讨其在听觉老化中的作用.结果显示,MeCP2蛋白在BALB/c小鼠耳蜗中有表达,主要为细胞核着色,并随月龄增长,小鼠耳蜗染色阳性程度变弱,阳性细胞比例减少... |
| 关 键 词： | 老化 耳蜗 免疫组化 MeCP2 |
Changes of MeCP2 in the Cochlea of BALB/c Mice during the Aging Process |
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| JIANG La-mei,ZHANG Yong,GE Sheng-lei,WU Wei-jing.Changes of MeCP2 in the Cochlea of BALB/c Mice during the Aging Process[J].ACTA Laser Biology Sinica,2011,20(1):74-77. | |
| Authors: | JIANG La-mei ZHANG Yong GE Sheng-lei WU Wei-jing |
| Institution: | JIANG La-mei~(1,2),ZHANG Yong~1,GE Sheng-lei~2,WU Wei-jing~(2*) (1.School of Medicine,Hunan Normal University,Changsha 410006,Hunan,China,2.Department of Otolaryngology-Head and Neck Surgery,the Second Xiangya Hospital,Central South University,Changsha 410011,China) |
| Abstract: | Based on the previous studies of auditory function measurement and cochlear morphological evaluation in BALB/c mice of different age,the expression and distribution of methyl-CpG-binding protein 2(MeCP2) in the cochlea of BALB/c mice were identified and compared among four age groups(3-,6-,12-and 18-month-old) by the immunohistochemical technique,which threw light on the effects of MeCP2 in the aging process of auditory system.The expression of MeCP2 was detected in the immunohistochemical staining study,pr... |
| Keywords: | MeCP2 |
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