| UDP-GalNAc:多肽N-乙酰氨基半乳糖转移酶-14 |
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| 引用本文： | 郭晓丹,吴琛,康现江.UDP-GalNAc:多肽N-乙酰氨基半乳糖转移酶-14[J].生命的化学,2010(1). |
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| 作者姓名： | 郭晓丹 吴琛 康现江 |
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| 作者单位： | 河北大学生命科学学院; |
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| 基金项目： | 国家自然科学基金项目(No.30800180); 河北省自然科学基金项目(No.C2009000191); 河北省教育厅科学研究计划(No.2008-106); 河北省科技支撑计划(No.07275552)资助 |
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| 摘 要： | UDP-GalNAc:多肽N-乙酰氨基半乳糖转移酶家族(简称GalNAc-T)是黏蛋白O-糖基化的起始酶,N-乙酰氨基半乳糖转移酶-14(GalNAc-T14)是该家族中最新发现的成员。近年来有人指出,O-糖基化可能与肿瘤的发生发展具有密切关系,因此对N-乙酰氨基半乳糖转移酶家族的研究也受到越来越多重视。本文主要综述了GalNAc-T14的命名、结构、分布、功能以及潜在的应用价值。
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| 关 键 词： | N-乙酰氨基半乳糖转移酶家族 GalNAc-T14 O-糖基化 肿瘤发生 |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14 |
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| Xiao-Dan Guo,Chen Wu,Xian-Jiang Kang College of Life Sciences,Hebei University,Baoding ,China.UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14[J].Chemistry of Life,2010(1). |
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| Authors: | Xiao-Dan Guo Chen Wu Xian-Jiang Kang College of Life Sciences Hebei University Baoding China |
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| Institution: | Xiao-Dan Guo,Chen Wu,Xian-Jiang Kang College of Life Sciences,Hebei University,Baoding 071002,China |
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| Abstract: | N-acetylgalactosaminyltransferases (GalNAc-Tases) catalyze the first step in the O-glycosylation of mucin proteins.GalNAc-T14 is a new member of glycosyltransferases family.Recent studies have demonstrated that O-glycosylation may be closely related to the carcinogenesis and development of tumours.Hence,studies on the N-acetylgalactosaminyltransferase family are getting more and more attention.The nomenclature,structure,distribution,function and the potential application value of GalNAc-T14 was reviewed in ... |
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| Keywords: | N-Acetylgalactosaminyltransferases GalNAc-T14 O-glycosylation carcinogenesis |
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