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Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies
Institution:1. MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK;2. Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK;1. Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland;2. University of Basel, Petersplatz 1, 4001 Basel, Switzerland;1. Department of Burns, Wound Repair and Reconstruction, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China;2. Department of Neurosurgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong, China;1. Gladstone Institute of Cardiovascular Disease, Gladstone Institutes, San Francisco, CA 94158, USA;2. UC Berkeley-UC San Francisco Graduate Program in Bioengineering, University of California, San Francisco, San Francisco, CA 94158, USA;3. Developmental and Stem Cell Biology Ph.D. Program, University of California, San Francisco, San Francisco, CA 94158, USA;4. Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA;5. Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA;6. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA;7. Center for iPS Cell Research and Application, Kyoto 606-8397, Japan;8. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA;1. Department of Frontier Life Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan;2. Department of Cell Growth and Differentiation, Center for iPS Cell Research & Application, Kyoto University, Kyoto 606-8507, Japan;3. Institute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany;4. Department of Industrial Life Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan;5. Center for Plant Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan;6. Laboratory for Ultrastructural Research, RIKEN Center for Biosystems Dynamics Research, Hyogo 650-0047, Japan;7. Department of Cell Biology, Tokushima University Graduate School of Medicine, Tokushima 770-8503, Japan;8. Research Core, Institute of Research, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;9. Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;10. Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore;11. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore;12. Japan Science and Technology Agency, PRESTO, Saitama 332-0012, Japan;1. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
Abstract:
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  • Keywords:senescence  cancer  tumor microenvironment  TME  senescence-associated secretory phenotype  SASP  senolytics
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