The protective effect of taurine pretreatment on carbon tetrachloride-induced hepatic damage--a light and electron microscopic study |
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| Authors: | Dinçer S Ozenirler S Oz E Akyol G Ozoğul C |
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| Institution: | (1) Department of Physiology,, TR;(2) Department of Gastroenterology,, TR;(3) Department of Pathology, and, TR;(4) Department of Histology, Gazi University Faculty of Medicine, Ankara, Turkey, TR |
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| Abstract: | Summary. The results regarding taurine pretreatment on CCl4-induced hepatic injury are controversial. To assess the therapeutic efficacy of taurine on rat liver injury, hepatic malondialdehyde,
glutathione, and hydroxyproline levels together with morphologic alterations in the liver following CCl4 administration were investigated. The rats were divided into three groups. Taurine-treated animals received 15 ml/kg/day
of a 5% taurine solution by a gastric tube for 5 days before administering CCl4 (2 ml/kg, intraperitoneally, in a single dose). CCl4-treated rats received the same amount of saline solution. Control animals received no treatment. The increase of hepatic
malondialdehyde formation in the CCl4-treated group was partially prevented by taurine pretreatment, but taurine had no significant effect on the glutathione and
hydroxyproline content in the CCl4-treated rats. Taurine pretreatment induced a marked beneficial effect regarding the prevention of hepatocellular necrosis
and atrophy as demonstrated morphologically. In conclusion, these results suggest that taurine pretreatment might not significantly
change the biochemical parameters, but prevents the morphologic damage caused by CCl4 in the early stages.
Received March 17, 2001 Accepted July 18, 2001 |
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| Keywords: | : Taurine Liver Carbon tetrachloride Malondialdehyde Glutathione Hydroxyproline Amino acids Light and electron microscopy |
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