蜘蛛肽类神经毒素研究进展

对目前已知一级结构的蜘蛛肽类神经毒素的结构和生理活性作了扼要的介绍，这类毒素基本上可分为短链（33-40个氨基酸残基）和长链（66-77个氨基酸残基）两大类.不同种属蜘蛛的肽类毒素之间在一级结构上同源性很小，在生理活性机制上有较大差异.其中某些毒素可选择性的作用于昆虫或脊推动物神经突触上钙与钠离子通道，显示出在神经生物学和神经药理学研究上有很大的应用前景.

Recent Advance on Spider Peptide Neurotoxin Research

The chemical structures and physiological functions of spider pepude neurotoxins have been reviewed and introduced. These neurotoxins can be classified briefly, into two groups according to their size. The short spider neurotoxins contain 33 to 40 amino acids residues, whereas the long ones have 66 to 77 residues. The homologies of the neurotoxins from different species are not evident and the physiological activities are quite difftirent. Some spider neurotoxins were found to selectively affect the sodium or calcium channels of the neuro-muscular system of the insect and vertebrate and were believed to be useful as tools in neurophysiology and pharmacology studies.