骨关节炎患者血清中ANA滴度与M蛋白鉴别的相关性

目的:探讨骨关节炎患者血清中抗核抗体(Antinuclear antibody,ANA)滴度与M蛋白(Ig G、Ig A、Ig M)鉴别的相关性。方法:2017年2月至2020年1月选择在本院诊治的骨关节炎患者220例作为骨关节炎组,同期选择在本院进行体检的健康人220例作为对照组,对比血清两组ANA滴度与Ig G、Ig A、Ig M蛋白表达情况及西大略湖和麦克马斯特(Western Ontario and McMaster Universities,WOMAC)骨关节炎指数评分,调查患者的一般资料并进行相关性分析。结果:骨关节炎组的WOMAC评分显著高于对照组(P<0.05)。骨关节炎组的血清ANA滴度的阳性和血清Ig G、Ig A、Ig M的表达水平均显著高于对照组(P<0.05)。在骨关节炎组,直线相关分析显示血清ANA滴度阳性与Ig G、Ig A、Ig M蛋白的表达水平、WOMAC评分均呈现显著正相关性(P<0.05)。二分类logistic逐步回归分析显示ANA滴度阳性、Ig G、Ig A、Ig M水平、病程为影响WOMAC评分的重要因素(P<0.05)。结论:骨关节炎患者血清中ANA滴度阳性、Ig G、Ig A、Ig M蛋白都呈现高表达状况,与患者的病情显著相关,也是影响骨关节炎发生与发展的重要因素。

Correlation between ANA Expression in Serum of Patients with Osteoarthritis and Identification of M Protein

ABSTRACT Objective: To investigate the correlation between antinuclear antibody (ANA) titer and M protein (IgG, IgA, IgM) identification. Methods: From February 2017 to January 2020, 220 osteoarthritis patients treated in our hospital were selected as the osteoarthritis group, and 220 healthy people who underwent physical examination in our hospital were selected as the control group. The serum ANA titers were compared between the two groups with IgG, IgA, IgM protein expression and WOMAC scores, investigate general information of patients and conduct correlation analysis. Results: The WOMAC score of the osteoarthritis group was significantly higher than that of the control group (P<0.05). Positive serum ANA titers and serum IgG, IgA and IgM levels in the osteoarthritis group were significantly higher than those in the control group (P<0.05). In the osteoarthritis group, a linear correlation analysis showed that the positive serum ANA titers were significantly positively correlated with the expression levels of IgG, IgA and IgM proteins, and WOMAC scores (P<0.05). Two-class logistic stepwise regression analysis showed that ANA titer, IgG, IgA, IgM levels, and course of disease were important factors affecting WOMAC score (P<0.05). Conclusion: Patients with osteoarthritis have positive ANA titers, IgG, IgA and IgM proteins are highly expressed, which is significantly related to the patient''s condition and is an important factor affecting the occurrence and development of osteoarthritis.