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| 斑蝥素及其衍生物的研究现状与应用 | |
| 引用本文： | 魏方超,杜娟 未宁宁 王岩 李尚伟.斑蝥素及其衍生物的研究现状与应用[J].现代生物医学进展,2012,12(8):1586-1589. |
| 作者姓名： | 魏方超 杜娟 未宁宁 王岩 李尚伟 |
| 作者单位： | 1. 贵州大学生命科学学院贵州 贵阳550025;贵州大学昆虫研究所分子生物学实验室 贵州贵阳550025 2. 贵州大学昆虫研究所分子生物学实验室 贵州贵阳550025 3. 沈阳药科大学中药学院 辽宁沈阳110016 4. 河南农业大学生命科学学院 河南郑州450002 |
| 摘 要： | 斑蝥素(Cantharidin)是一种可从昆虫斑蝥虫体提取或人工合成的具有抗肿瘤作用的药物,因其毒性强烈,受限于临床应用。人工合成的斑蝥素衍生物如去甲斑蝥素、斑蝥酸钠、去甲斑蝥酸钠、甲基斑蝥胺等,毒性低,疗效显著。本文对斑蝥素及其衍生物在抗肿瘤作用及分子机理方面的研究现状进行综述,为充分利用斑蝥素这一中药资源提供参考。 |
| 关 键 词： | 斑蝥素 衍生物 抗肿瘤 细胞凋亡 |
Progress and Application of Cantharidin and Its Derivatives |
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| WEI Fang-chao,DU Juan,WEI Ning-ning,WANG Yan,LI Shang-wei.Progress and Application of Cantharidin and Its Derivatives[J].Progress in Modern Biomedicine,2012,12(8):1586-1589. | |
| Authors: | WEI Fang-chao DU Juan WEI Ning-ning WANG Yan LI Shang-wei |
| Institution: | 1 College of Life Sciences,Guizhou University,Guiyang,550025,China; 2 Laboratory of Molecular Biology,Institute of Entomology,Guizhou University,Guiyang,550025,China; 3 College of Traditional Chinese Medicine,Shenyang Pharmaceutical University,Shenyang,110016,China; 4 College of Life Sciences,Henan Agricultural University,Zhengzhou,450002,China) |
| Abstract: | Cantharidin is an antineoplastic drug that can be extracted from cantharis or artificially synthesized.However,clinical application of cantharidin is limited because of its strong toxicity.Synthetic cantharidin derivatives such as norcantharidin,sodium cantharidate,sodium demethylcantharidate and methylcantharidinimide,have notable curative effects with low toxicity.In this paper,research progress on the antitumor activities and molecular mechanisms of cantharidin and its derivatives was summarized,in order to make full use of the traditional Chinese medicine resources. |
| Keywords: | Cantharidin Analogue Antitumor Apoptosis |
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