妊娠糖尿病患者血清HbA1c与CRP水平的相关性分析

目的:为明确妊娠期糖尿病(gestational diabetes mellitus,GDM)患者血清糖化血红蛋白(glycosylated hemoglobin,Hb A1c)与C反应蛋白(C-reactive protein,CRP)的关系,本研究检测了GDM患者血糖、血清Hb A1c与CRP水平,并对Hb A1c与CRP的相关性进行了分析。方法:以68例2015年4月至2017年4月于我院诊治的GDM孕妇为研究对象,所有患者均符合《妇产科学》中关于GDM的诊断标准,另选取68例正常孕妇为对照组。采用葡萄糖氧化酶法检测血糖水平(空腹血糖及餐后2 h血糖水平),采用免疫凝集法检测和比较两组血清糖化血红蛋白(HbA1c)水平,采用免疫透射比浊法检测血清C反应蛋白(CRP)水平,并分析HbA1c与CRP的相关性。结果:GDM组患者空腹血糖(fasting plasma glucose,FPG)、2 h血糖(plasma glucose,PG)、血清HbA1c和CRP水平均显著高于正常组(P0.05),GDM患者血清Hb A1c和CRP水平呈显著正相关关系(r=0.654,P0.05)。结论:GDM患者血清HbAlC和CRP水平相较于正常孕妇有显著提高,且二者呈显著的正相关关系,二者联合检测可能作为GDM早期诊断的筛查的重要参考指标。

The Correlation Analysis of Serum HbA1c and CRP in Patients with Gestational

ABSTRACT Objective: To determine the relationship between serum glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP) in patients with gestational diabetes mellitus (GDM). In this study, blood glucose levels, serum HbA1c and CRP were measured in patients with GDM and the correlation between HbA1c and CRP was studied. Methods: A total of 68 pregnant women with gestational diabetes mellitus diagnosed and treated in our hospital from April 2015 to April 2017 were selected as research objects. All patients were in line with "Obstetrics and Gynecology" in the diagnostic criteria for GDM, and the other 68 normal pregnant women as the control group. There was no significant difference between the two groups in the general information of the study subjects, and the inclusion and exclusion criteria were met. Glucose oxidase method was used to test the blood glucose level (fasting blood glucose and postprandial 2h blood glucose level). Immunoagglutination method was used to detect serum HbA1c, Immunoturbidimetry was used to detect the C-reac- tive protein (CRP). The differences between the two groups were compared, and the correlation between HbA1c and CRP was studied. All data were analyzed by SPSS 20.0, t-test and correlation analysis were used to analyze the data. The difference was statistically signifi- cant at P<0.05. Results: The levels of fasting plasma glucose (FPG) and 2 h plasma glucose (PG) in GDM pregnant women and normal pregnant women were significantly higher than those in normal controls (P<0.05). In this study, serum levels of HbA1c and CRP were measured in patients with GDM and normal controls. The levels of HbA1c and CRP in patients with GDM were significantly higher than those in normal controls (P<0.05). Correlation analysis of serum HbA1c level and CRP level in pregnant women with GDM showed that there was a significant positive correlation between HbA1c and CRP levels in GDM patients (r=0.654, P<0.05). Conclusion: The serum HbAlC and CRP levels were significantly upregulated in GDM patients. There was a significant positive correlation between serum HbA1c and CRP levels in GDM patients. Combined detection of serum HbAlC and CRP levels couls be used as an important indicator of early diagnosis of GDM.