Lipopeptide surfactants: Production,recovery and pore forming capacity |
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| Institution: | 1. Higher Institute of Biotechnology, Tunisia;2. Unit Enzymes and Bioconversion, National School of Engineers, Tunisia;1. Institute of Biology, Ufa Research Centre of Russian Academy of Sciences, 450054 Ufa, Russia;2. Division of Microbiology, Department of Food and Environmental Sciences, University of Helsinki, Viikki Biocenter, P.O. Box 56, 00014 Helsinki, Finland;3. Department of Chemistry, University of Turku, 20014 Turku, Finland;4. Technology Research Centre, University of Turku, 20520 Turku, Finland;5. Turku Centre for Biotechnology, University of Turku and ?bo Academi, 20520 Turku, Finland;6. Structural Biology Program, Sloan-Kettering Institute for Cancer Research, 10021 NY, United States;7. Department of Virology, Institute of Microbiology and Pathology, University of Turku, 20520 Turku, Finland;1. Institute of Plant Protection, Hebei Academy of Agricultural and Forestry Sciences, Integrated Pest Management Center of Hebei Province, Key Laboratory of IPM on Crops in Northern Region of North China, Ministry of Agriculture, Baoding 071000, China;2. Agricultural College, Agricultural University of Hebei, Baoding 071000, China;3. Wood Science Department, University of British Columbia, Vancouver V6T1Z4, Canada |
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| Abstract: | Lipopeptides are microbial surface active compounds produced by a wide variety of bacteria, fungi and yeast. They are characterized by highly structural diversity and have the ability to decrease the surface and interfacial tension at the surface and interface, respectively. Surfactin, iturin and fengycin of Bacillus subtilis are among the most studied lipopeptides. This review will present the main factors encountering lipopeptides production along with the techniques developed for their extraction and purification. Moreover, we will discuss their ability to form pores and destabilize biological membrane permitting their use as antimicrobial, hemolytic and antitumor agents. These open great potential applications in biomediacal, pharmaceutic and agriculture fields. |
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| Keywords: | Lipopeptides Surfactants Production Biosynthesis Extraction Purification Biological activities Antimicrobials |
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