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| ProEx C 在宫颈癌及其癌前病变中的表达及意义 | |
| 引用本文： | 张蕾,王霞,张珊,杨彦华,石纳玉,蔡广彦.ProEx C 在宫颈癌及其癌前病变中的表达及意义[J].现代生物医学进展,2011,11(20):3878-3881. |
| 作者姓名： | 张蕾 王霞 张珊 杨彦华 石纳玉 蔡广彦 |
| 作者单位： | 1. 青岛大学医学院山东 青岛266000 2. 青岛市市立医院山东 青岛266001 3. 青岛经第八人民医院山东 青岛266000 |
| 摘 要： | 目的:探讨ProEx C在宫颈癌及其癌前病变中的表达及意义。方法:应用免疫组织化学SP法检测ProEx C在不同宫颈病变组织芯片中的表达。结果:ProEx C在宫颈炎、CINI、CINII、CINIII及宫颈癌中的阳性表达率分别是25%,51.7%,77.9%,90%,93.8%,且其表达在宫颈癌及CINIII级病变与宫颈炎及CINI级病变相比较差异具有统计学意义(P<0.05),ProEx C在CINI级组织中表达低于CINII级,差异具有统计学意义(P<0.05),ProEx C在浸润性宫颈癌中的表达与临床病理因素无关(P>0.05)。结论:ProEx C反映了细胞的增殖活性,促进宫颈癌的发生发展,可作为诊断及监测预后的指标。 |
| 关 键 词： | 子宫颈癌 子宫颈癌前病变 ProExC组织芯片 免疫组化 |
Expression and Significance of ProEx C in Cervical Cancer and Cervical Intraepithelial Noplasia |
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| ZHANG Lei,WANG Xi,ZHANG Shan,YANG Yan-hu,SHI Na-yu,CAI Guang-yan.Expression and Significance of ProEx C in Cervical Cancer and Cervical Intraepithelial Noplasia[J].Progress in Modern Biomedicine,2011,11(20):3878-3881. | |
| Authors: | ZHANG Lei WANG Xi ZHANG Shan YANG Yan-hu SHI Na-yu CAI Guang-yan |
| Institution: | ZHANG Lei1,WANG Xia2,ZHANG Shan3,YANG Yan-hua2,SHI Na-yu3,CAI Guang-yan3(1 The Medical College of Qingdao University,Qingdao266021,China,2 Qingdao Municipal Hospital,266011,Qingdao,3 The Eighth hospital of Qingdao,2666000,China) |
| Abstract: | Objective:To explore the expression and significance of ProEx C in cervical cancer and cervical intraepithelial neoplasia.Methods:The expressions of ProEx C in the cervical tissue microarray were detected by immunohistochemical SP methods.Results:The positive rate of ProEx C in chronic cervicitis,CINI,CINII,CINIII and cervical cancer were 25%,51.7%,77.9%,90%,93.8% respectively.The expression levels of ProEx C in cervical cancer and CINIII were significantly higher than those in cervicitis and CINI tissues(P... |
| Keywords: | Cervical cancer Cervical intraepithelial neoplasia ProEx C Tissue microarray Immunohistochemistry |
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