Low incidence of bronchus-associated lymphoid tissue (BALT) in chronically inflamed human lungs |
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Authors: | S Delventhal A Brandis H Ostertag R Pabst |
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Institution: | 1. Centre of Anatomy, Medical School of Hannover, Hannover, Federal Republic of Germany 2. Institute of Pathology, Nordstadt Hospital, Hannover, Federal Republic of Germany
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Abstract: | The relevance of bronchus-associated lymphoid tissue (BALT) in man is still under discussion. Animal experiments indicate
that the development of BALT is dependent on microbial stimulation. Therefore, the incidence of BALT was investigated retrospectively
in specimens removed during surgical procedures on patients with chronic pulmonary inflammation. All these patients had severe
chronic bronchitis and bronchiectasis, but BALT was found in only 8%. In patients with BALT and a malignant tumor, occlusion
of a bronchus with poststenotic pneumonia was always present and BALT was observed exclusively in areas peripheral to the
occlusion. In man other compartments of the lung must be responsible for the immune function of BALT found in animals.
Partly presented at the Congress of the Eur. Respir. Soc, 21.- 26.9.1991 in Brussels. (Abstract: Eur Respir J. 4, Suppl. 14:217p) |
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Keywords: | Bronchus-associated lymphoid tissue (BALT) Chronic inflammation Man Histology Mucosal immune system |
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