| 肿瘤DNA疫苗佐剂研究进展 |
| |
| 引用本文： | 蒋鸿超,李鸿钧,孙茂盛.肿瘤DNA疫苗佐剂研究进展[J].生物技术,2005,15(6):89-93. |
| |
| 作者姓名： | 蒋鸿超 李鸿钧 孙茂盛 |
| |
| 作者单位： | 中国医学科学院,中国协和医科大学,医学生物学研究所,云南,昆明,650118 |
| |
| 摘 要： | 对近年来在增加肿瘤DNA疫苗免疫原性、提高肿瘤DNA疫苗效力方面所取得的进展予以综述。简要阐述了以下几种较有效的增强肿瘤DNA疫苗效力策略的机制和进展：（1）以细胞因子表达质粒为佐剂；（2）以质粒编码的趋化因子、协同刺激分子、共刺激分子、补体为佐剂；（3）以CPGODN为佐剂；（4）其他一些佐剂。
|
| 关 键 词： | 肿瘤DNA疫苗 细胞因子 趋化因子 CpG ODN 分子佐剂 |
| 文章编号： | 1004-311X（2005）06-0089-05 |
| 收稿时间： | 2005-06-13 |
| 修稿时间： | 2005-10-20 |
Advances in the Researches of Enhancing Immune Responses of Tumor DNA Vaccine |
| |
| JIANG Hong-chao,LI Hong-jun,SUN Mao-sheng.Advances in the Researches of Enhancing Immune Responses of Tumor DNA Vaccine[J].Biotechnology,2005,15(6):89-93. |
| |
| Authors: | JIANG Hong-chao LI Hong-jun SUN Mao-sheng |
| |
| Institution: | Institute of Medical Biology,CAMS and PUMC, Kunming 650118, China |
| |
| Abstract: | Tumor DNA vaccine can elicit relatively low immune response comparing with traditional vaccine in human being.So this limits the application of tumor DNA vaccine.This review summarizes the most recent findings of enhancing immune effects of tumor DNA Vaccine.There are several immune mechamisms and strategies have been used to improve and modulate more effective immune response induced by tumor DNA vaccines:(1)plasmid encoding cytokines(2) plasmid encoding costimulatory molecules and chemokine and complements(3)CpG ODN(4) targeting APCs,construction of plasmids and inoculation routes et al. |
| |
| Keywords: | tumor DNA vaccine cytokines chemokines CPG ODN molecule adjuvant |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
