血清Visfatin、PRDX1水平与克罗恩病患者活动度指标和肠道菌群的相关性分析

摘要 目的：分析血清内脂素（Visfatin）、过氧化物还原蛋白1（PRDX1）水平与克罗恩病（CD）患者活动度指标和肠道菌群的相关性。方法：选取2019年4月~2022年12月期间联勤保障部队第九一〇医院收治的146例CD患者，根据简化克罗恩病疾病活动指数（CDAI）将所有CD患者分为中重度活动组（n=36）、轻度活动组（n=49）、缓解期组（n=61）。对比三组血清Visfatin、PRDX1、C反应蛋白（CRP）水平、血沉（ESR）、肠道菌群数量。采用Pearson相关性分析血清Visfatin、PRDX1与 CDAI、 CRP、ESR和肠道菌群数量的相关性。结果：中重度活动组、轻度活动组的血清Visfatin、PRDX1水平高于缓解期组，且中重度活动组血清Visfatin、PRDX1水平高于轻度活动组（P<0.05）。中重度活动组、轻度活动组的CRP、ESR高于缓解期组，且中重度活动组CRP、ESR高于轻度活动组（P<0.05）。中重度活动组、轻度活动组的肠球菌、大肠杆菌高于缓解期组，且中重度活动组的肠球菌、大肠杆菌高于轻度活动组（P<0.05），中重度活动组、轻度活动组的双歧杆菌、类杆菌低于缓解期组，且中重度活动组的双歧杆菌、类杆菌低于轻度活动组（P<0.05）。Pearson相关性分析显示，血清Visfatin、PRDX1、 CRP水平与 肠球菌、大肠杆菌菌群数量、CDAI、ESR呈正相关，而与双歧杆菌、类杆菌菌群数量呈负相关（P<0.05）。结论：CD患者的血清Visfatin、PRDX1升高，可导致疾病进展，肠道菌群紊乱加重。

Correlation Analysis of Aerum Visfatin and PRDX1 Levels with Activity Index and Intestinal Flora in Patients with Crohn's Disease

ABSTRACT Objective: The correlation between serum visfatin and peroxiredoxin 1 (PRDX1) levels and activity indexes and intestinal flora in patients with Crohn''s disease(CD) was analyzed. Methods: 146 CD patients who were admitted to the 910th Hospital of the Joint Logistics Support Force from April 2019 to December 2022 were selected, all CD patients were divided into mild moderate to severe activity group (n=36), activity group (n=49), remission group (n=61) according to the simplified Crohn''s disease activity index (CDAI). Serum Visfatin, PRDX1, CRP levels, ESR, and intestinal flora were compared among three groups. The correlation between serum Visfatin, PRDX1 and CDAI, C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR) and intestinal flora were analyzed by Pearson correlation analysis. Results: The levels of serum visfatin and PRDX1 in moderate to severe activity group and mild activity group were higher than those in remission group, and the levels of serum Visfatin and PRDX1 in moderate to severe activity group were higher than those in mild activity group(P<0.05). The CRP and ESR in moderate to severe activity group and mild activity group were higher than those in remission group, and the CRP and ESR in moderate to severe activity group were higher than those in mild activity group(P<0.05). The enterococcus and escherichia coli in moderate to severe activity group and mild activity group were higher than those in remission group, and the enterococcus and escherichia coli in moderate to severe activity group were higher than those in mild activity group (P<0.05), the bacillus bifidus and bacteroides in moderate to severe activity group and mild activity group were lower than those in remission group, and the bacillus bifidus and bacteroides in moderate to severe activity group were lower than those in mild activity group(P<0.05). Pearson correlation analysis showed that, serum Visfatin, PRDX1 and CRP levels were positively correlated with the number of enterococcus and escherichia coli flora, CDAI and ESR, but negatively correlated with the number of bacillus bifidus and bacteroides flora(P<0.05). Conclusion: The levels of serum Visfatin and PRDX1 in CD patients are increase, which can lead to disease progression and aggravation of intestinal flora disorder.