Effects of Chronic Ethanol Administration on Serotonin Metabolism in the Various Regions of the Rat Brain |
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Authors: | Uzbay ? T Usanmaz S E Akarsu E S |
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Institution: | (1) Department of Pharmacology, Faculty of Medicine, Gülhane Military Medical Academy, Etlik, 06018 Ankara, Turkey;(2) Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Ankara University, Ankara, Turkey |
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Abstract: | Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was performed in two groups of ethanol-treated and control rats (n = 6 for each group). Rats in each group were decapitated at the 10th and 21st days of ethanol consumption. Brains were removed and cerebral cortex, corpus striatum and hippocampus were dissected. 5-HT and 5-HIAA levels were measured in respective brain regions by using high performance liquid chromatography. In cerebral cortex and corpus striatum, 5-HT levels were significantly lower than control at the 10th day of ethanol consumption. At the 21st day, the levels tended to remain low, but not significantly different statistically. In hippocampus, 5-HIAA levels were significantly higher than control at 10th day of ethanol consumption. Increased 5-HIAA level returned to control values at the 21st day of ethanol consumption. Our results suggest that, 5-HT clearly seems to play a critical role in the brain at the 10th day of chronic ethanol consumption. |
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Keywords: | Ethanol chronic ethanol administration ethanol dependence serotonin 5-hydroxy indole acetic acid rat brain regions |
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