| HLA—DRB1等位基因的多态性及其应用 |
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| 引用本文： | 刘越,;郭永晨,;米佳,;黄耀江,;张琳霞,;冯金朝.HLA—DRB1等位基因的多态性及其应用[J].生物磁学,2008(5):973-976. |
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| 作者姓名： | 刘越 ;郭永晨 ;米佳 ;黄耀江 ;张琳霞 ;冯金朝 |
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| 作者单位： | [1]中央民族大学生命与环境科学学院,北京100081; [2]中国民族地区环境资源保护研究所,北京100081 |
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| 基金项目： | 国家科技基础条件平台工作（2005DKA21601-10（01））与国家985工程项目（CUN985-3-3）,中央民族大学青年教师科研基金（CUN0239）项目资助 |
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| 摘 要： | HLA系统参与和调节机体免疫功能，是人类重要叫遗传标志，具有种族、地域差异。HLA—Ⅱ类系统中DRB1等位基因的多态性最丰富，它的准确分型直接影响器官移植的供体选择、法医学个体认定、HLA与疾病相关性及人类学等研究。本文综述了HLA—DRB1分型检测方法，不同种族人群HLA-DRB1等位基因的多态性，HLA—DRB1多态性研究在探讨人类起源、民族融合方面的价值，HLA—DRB1与肝炎、系统性红斑狼疮等疾病的相关性等。
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| 关 键 词： | HLA—DRB1 多态性 人类学 疾病 相关性 |
Polymorphism and Application of HLA-DRB 1 Alleles |
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| Institution: | LIU Yue, GUO Yong-chen, MI Jia, HUANG Yao-jiang, ZHANG Lin-xia, FENG Jin-chao (1 College of Life ＆ Environment, Central University for Nationah＇ties, Beijing, 100081, China; 2 Chinese Institute of Environment ＆ Resources Protection for Minority Nationality Areas, Beijing, 100081, China) |
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| Abstract: | The HLA system is a very important genetic marker for human beings with the race and region differences, which participates in and adjusts immunity function. HLA-DRB 1 allele genes have the highest polymorphism in HLA class Ⅱ. The accurate classification of HLA-DRB 1 directly affects the donor selection in organ transplant, individual identification in forensic medicine, disease-correlation, and anthropology research. HLA-DRB 1 polymorphism in different people, its value in the human origin and national fusion, the typing and detecting methods of HLA-DRB 1,the correlation between HLA-DRB 1 and HBV or SLE were reviewed in this article. |
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| Keywords: | HLA-DRB 1 Polymorphism Anthropology Disease Correlation |
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