| ERK1/2和p-ERK1/2在肺癌组织中的表达及意义 |
| |
| 引用本文： | 谷艳娇,包翠芬,魏嘉,梁佳,高志安.ERK1/2和p-ERK1/2在肺癌组织中的表达及意义[J].中国组织化学与细胞化学杂志,2009,18(3):328-332. |
| |
| 作者姓名： | 谷艳娇 包翠芬 魏嘉 梁佳 高志安 |
| |
| 作者单位： | 1. 辽宁医学院附属第一医院病理科
2. 辽宁医学院科学实验中心,辽宁,锦州,121000 |
| |
| 摘 要： | 目的研究细胞外信号调节激酶1/2（extracellular regulated kinase 1/2,ERK1/2）及其磷酸化状态（p-ERK1/2）在不同分化程度肺癌中的表达情况,探讨二者与肺癌侵袭、转移的关系。方法采用免疫组化（Envision）法,检测79例肺癌组织及l2例癌旁正常肺组织中ERK1/2和p-ERK1/2的表达。结果ERK1/2在高、中、低分化组表达率分别为13.6%,39.4%,66.7%,p-ERK1/2在高、中、低分化组表达率分别14.3%,27.3%,79.2%（P〈0.05）;无淋巴结转移者阳性率为20%,有淋巴结转移者阳性率为50.1%（P〈0.05）。ERK1/2和p-ERK1/2的表达在不同年龄、性别、肿瘤大小、肿瘤病理类型无显著性差异,而与分化程度有关,其中p-ERK1/2的表达还与有无淋巴结转移有关。结论ERK1/2和p-ERK1/2在肺癌组织中高表达且与分化程度有关。
|
| 关 键 词： | ERK1/2 p-ERK1/2 肺癌 免疫组化 |
EXPRESSION AND SIGNIFICANCE OF ERK1/2 AND P-ERK1/2 IN HUMAN LUNG CANCER |
| |
| Gu Yanjiao,Bao Cuifen,Weijia,Liangjia,Gao Zhian.EXPRESSION AND SIGNIFICANCE OF ERK1/2 AND P-ERK1/2 IN HUMAN LUNG CANCER[J].Chinese Journal of Histochemistry and Cytochemistry,2009,18(3):328-332. |
| |
| Authors: | Gu Yanjiao Bao Cuifen Weijia Liangjia Gao Zhian |
| |
| Institution: | Gu Yanjiao1,Bao Cuifen2,Weijia2,Liangjia2,Gao Zhian1(1Department of Pathology,The First Affiliated Hospital,2Center of Scientific Experiment,Liaoning Medical college,Jinzhou 121000,China) |
| |
| Abstract: | Objective To detect the expression of ERK1/2 and p-ERK1/2 in different lung cancer and research the relationship between the two factors and the lung cancer.Methods The expression of ERK1/2 and p-ERK1/2 in different human lung cancers were detected by immunohistochemistry techniques.Results The expression of ERK in the poorly,moderate and well differentiated groups was 13.6%,39.4% and 66.7%,respectively,while the expression of p-ERK1/2 was 14.3%,27.3% and 79.2%(P<0.05).The positive rate was 51.3% in cases w... |
| |
| Keywords: | ERK1/2 p-ERK1/2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
