大麻素受体2在吗啡耐受中的作用

吗啡在疼痛治疗中广泛应用,但其长期使用可以导致耐受,这大大影响了其临床应用价值,吗啡耐受是临床亟待解决的问题。研究发现大麻素受体2(cannabinoid receptor 2,CB2受体)参与吗啡耐受的发生与发展。CB2受体选择性激活剂与吗啡联合使用,可以减弱吗啡诱导产生的痛觉过敏和异常疼痛,抑制吗啡耐受的发生与发展。激活CB2受体抑制吗啡耐受的机制尚未明确,本文将就CB2受体在吗啡耐受中作用的研究现状作一综述。

The Role of Cannabinoid Receptor 2 in Morphine Tolerance

Morphine is widely used in the treatment of pain, but its long-termuse can lead to tolerance, which greatly affected its clinical value. Morphine tolerance is a clinical problems to be solved. Studies have found cannabinoid receptors 2 involved in the occurrence and development of morphine tolerance. Selective CB2 receptor activator combined with morphine, can attenuate morphine induced hyperalgesia and allodynia, inhibition of morphine tolerance. The mechanisms of that CB2 receptor activation inhibits morphine tolerance are not clear yet, which provides an overview of the role of the CB2 receptor in morphine tolerance.