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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Authors:Mikolaj Ogrodnik  Yi Zhu  Larissa GP Langhi  Tamar Tchkonia  Patrick Krüger  Edward Fielder  Stella Victorelli  Rifqha A Ruswhandi  Nino Giorgadze  Tamar Pirtskhalava  Oleg Podgorni  Grigori Enikolopov  Kurt O Johnson  Ming Xu  Christine Inman  Allyson K Palmer  Marissa Schafer  Moritz Weigl  Diana Jurk
Institution:1. Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK;2. Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;3. Department of Anesthesiology, Stony Brook School of Medicine, 101 Nicolls Road, Stony Brook, New York, NY 11794, USA;4. Center for Developmental Genetics, Stony Brook University, 100 Nicolls Road, Stony Brook, New York, NY 11794, USA;5. Department of Nano-, Bio-, Information Technology and Cognitive Science, Moscow Institute of Physics and Technology, Moscow, Russia;6. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA;7. The Barshop Institute for Longevity and Aging Studies, San Antonio, Department of Pathology, The University of Texas Health Science Center at San Antonio, Research Service, Audie L. Murphy VA Hospital (STVHCS), San Antonio, TX 78229, USA;8. Departments of Neurologic Surgery and Neuroscience, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA;9. Near East University, Arts and Sciences Faculty, Molecular Biology and Genetics, Nicosia, North Cyprus POB 99138 Mersin 10, Turkey;10. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA
Abstract:
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  • Keywords:Corresponding author  aging  senescence  obesity  anxiety  anxiety-like behavior  neurogenesis  high-fat diet  brain  stem cells  lipid droplets
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