颅脑损伤后创伤后应激障碍的研究进展

创伤后应激障碍(PTSD)是临床上常见的应激后反应,多见于重大创伤后,具有发病率高、临床表现复杂、治疗难度大等特点,已成为世界范围内广泛关注的公共卫生问题。颅脑损伤是引起PTSD的重要因素,近年来针对颅脑损伤后PTSD展开了一系列研究。本文通过回顾近年来有关颅脑损伤后PTSD的基础与临床研究,对颅脑损伤与PTSD相关性的流行病学特征、发病机制、诊断与鉴别以及药物和心理治疗中的进展和面临的困难进行综述,以期为颅脑损伤后PTSD的深入研究提供理论依据和新思路。

Research Progress on the Post-traumatic Stress Disorders after Brain Trauma

ABSTRACT: Post-traumatic stress disorder (PTSD) is a common clinical syndrome after exposure to stress mainly caused by severe traumatic event, characterized by high incidence, complex clincial feature, and difficult therapy. It has raised widespread concerns as public health problem. Brain trauma is an important incentive of PTSD. There are several studies on PTSD after brain trauma in recent years. After summarized recent basic and clincial studes on PTSD after brain trauma, this paper reviewed the recent progress and difficul- ties in epidemiological studies, pathogenesis, diagnosis, and treatment of PTSD after brain trauma, in order to provide theoretical basis and new thinking for PTSD after brain trauma.