About possible functional interaction between serotonin and neuropeptides in control processes of embryogenesis (Experiments on embryos ofTritonia diomedea) |
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| Authors: | A O D Willows L A Nikitina V V Bezuglov N M Gretskaya G A Buznikov |
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| Institution: | (1) Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 117808 Moscow, Russia;(2) Washington University, Washington, USA;(3) Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117871 Moscow, Russia |
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| Abstract: | Ritanserin and inmecarb hydrochloride, antagonists of serotonin, act cytostatically and teratogenically on early embryos ofTritonia diomedea, a nudibranch mollusk. On the basis of a pharmacological analysis and the type of developmental abnormalities observed, this
action appears to be due to disturbances in the functional activity of endogenous serotonin and is associated with damage
to the cytoskeleton. The effects of ritanserin and inmecarb are prevented or attenuated by lipophilic serotonin analogs (serotoninamides
of polyenoic fatty acids), as well as by polypeptides isolated from neurons Pd5 and Pd6 of the pedal ganglia of the adultTritonia. In late embryos (stage of veligers), serotonin and to a lesser extent its lipophilic analogs strongly increase embryonic
motility. This effect of serotonin is potentiated by some neuropeptides and inhibited by others. These results provide evidence
for functional interaction between serotonin and neuropeptides in the control processes of embryogenesis. |
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| Keywords: | serotonin serotoninamides of fatty acids neuropeptides identified neurons cleavage divisions embryonic motility Tritonia diomedea |
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