血清降钙素原在脓毒症患儿中的应用价值分析

目的:探讨脓毒症患儿血清降钙素原(PCT)水平变化及临床应用价值。方法:对脓毒症组38例患儿(严重脓毒症组16例、非严重脓毒症组22例)血清PCT、C反应蛋白(CRP)水平和白细胞(WBC)计数等指标进行检测,并与非脓毒症组的40例患儿进行比较分析。结果:脓毒症组患儿血清PCT、CRP水平及WBC计数均显著高于非脓毒症组,差异具有统计学意义(P<0.05);血清PCT、CRP水平对诊断脓毒症的敏感性差异无显著性(P>0.05),均显著高于WBC计数,差异具有统计学意义(P<0.05);血清PCT水平特异性、阳性预测值、阴性预测值及约登指数均显著高于CRP和WBC计数,差异具有统计学意义(P<0.05);严重脓毒症组患儿血清PCT水平显著高于非严重脓毒症组,差异具有统计学意义(P<0.05),而两组间血清CRP水平及WBC计数差异不显著(P>0.05)。结论:PCT可作为敏感性的鉴别诊断患儿脓毒症的血清学指标,其效果优于CRP和WBC计数。

Application Value Analysis of Detecting Serum Procalcitonin Levels in Sepsis Children

Objective: To explore the clinical significance of detecting the serum procalcitonin(PCT) level in children with sepsis.Methods: The serum PCT levels,C-reactive protein(CRP) levels and white blood cell(WBC) count were detected in 38 patients(16 chil-dren with severe sepsis,22 children with non-severe sepsis),and compared with 40 children without sepsis.Results: The serum PCT lev-els,CRP and WBC count in the sepsis group were significantly higher than non-sepsis group,the difference was statistically significant(P<0.05).The sensitivity of PCT,CRP in the diagnosis of sepsis wasn’t statistically significant(P>0.05),but it was significantly higher than WBC count,the difference was statistically significant(P<0.05).The specificity,positive predictive value,negative predictive value,Youden index of PCT were significantly higher than CRP and WBC count,the difference was statistically significant(P<0.05);The serum PCT level in the severe sepsis group was significantly higher than that non-severe sepsis group,the difference was statistically signifi-cant(P<0.05),but the serum levels of CRP and WBC count had no significant difference between the two groups(P>0.05).Conclusions: PCT could be used as a sensitive serum marker in diagnosing sepsis in children.The effect of PCT is superior to CRP and WBC count.