甲状腺癌超声弹性成像定量参数与叉头盒A1、Yes相关蛋白的相关性研究

摘要 目的：探讨甲状腺癌患者的超声弹性成像（UE）定量参数及其与叉头盒A1（FOXA1）、Yes相关蛋白（YAP）的相关性。方法：选择2019年3月-2020年10月于本院就诊的142例甲状腺结节患者的临床资料，所有患者均为单发甲状腺结节，根据病理结果分为恶性组（72例，72个甲状腺结节）与良性组（70例，70个甲状腺结节），所有患者行UE检查、组织活检。比较恶性组与良性组的弹性评分、应变率比值（SR）的差异，并分析恶性组的弹性评分、SR值与FOXA1、YAP的相关性。结果：恶性组的弹性评分、SR值显著高于良性组，差异有统计学意义（P<0.05）。恶性组FOXA1、YAP表达显著高于良性组，差异有统计学意义（P<0.05）。恶性组的弹性评分、SR值与FOXA1、YAP表达呈正相关（P<0.05）。结论：甲状腺结节恶性组与良性组的弹性评分、SR值及FOXA1、YAP表达的差异显著，且恶性组的弹性评分、SR值与其FOXA1、YAP表达呈正相关，UE定量参数在一定程度上可反映甲状腺癌患者的恶性的生物学行为。

Correlation between Ultrasound Elastography Quantitative Parameters and Forkhead Box A1 and Yes-Associated Protein in Thyroid Cancer

ABSTRACT Objective: To investigate the ultrasound elastography(UE) quantitative parameters in patients with thyroid cancer and their correlation with Forkhead box A1 (FOXA1) and Yes-associated protein (YAP). Methods: The clinical data of 142 patients with thyroid nodules treated in our hospital from March 2019 to October 2020 were selected. All patients were single thyroid nodules. According to the pathological results, they were divided into malignant group (72 cases, 72 thyroid nodules) and benign group (70 cases, 70 thyroid nodules). All patients underwent UE examination and tissue biopsy. The differences of elasticity score and strain rate ratio(SR) between malignant group and benign group were compared, and the correlation between elasticity score, SR value and FOXA1,YAP of malignant group was analyzed. Results: The elasticity score and SR value of malignant group were significantly higher than those of benign group, the difference was statistically significant(P<0.05). The expressions of FOXA1 and YAP in malignant group were significantly higher than those in benign group, the difference was statistically significant(P<0.05). The elasticity score, SR value were positively correlated with the expression of FOXA1 and YAP of malignant group(P<0.05). Conclusion: There were significant differences in elasticity score, SR value and FOXA1, YAP expression between malignant group and benign group of thyroid nodule,and the elasticity score, SR value of malignant group were positively correlated with FOXA1, YAP expression. UE quantitative parameters can reflect the malignant biological behavior of patients with thyroid cancer to a certain extent.